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dc.contributor.authorBalakrishnan, Rama
dc.contributor.authorHarris, Midori
dc.contributor.authorHuntley, Rachael
dc.contributor.authorVan Auken, Kimberly
dc.contributor.authorCherry, J Michael
dc.date.accessioned2018-10-10T05:17:03Z
dc.date.available2018-10-10T05:17:03Z
dc.date.issued2013
dc.identifier.issn1758-0463
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/283361
dc.description.abstractThe Gene Ontology Consortium (GOC) is a community-based bioinformatics project that classifies gene product function through the use of structured controlled vocabularies. A fundamental application of the Gene Ontology (GO) is in the creation of gene product annotations, evidence-based associations between GO definitions and experimental or sequence-based analysis. Currently, the GOC disseminates 126 million annotations covering >374,000 species including all the kingdoms of life. This number includes two classes of GO annotations: those created manually by experienced biocurators reviewing the literature or by examination of biological data (1.1 million annotations covering 2226 species) and those generated computationally via automated methods. As manual annotations are often used to propagate functional predictions between related proteins within and between genomes, it is critical to provide accurate consistent manual annotations. Toward this goal, we present here the conventions defined by the GOC for the creation of manual annotation. This guide represents the best practices for manual annotation as established by the GOC project over the past 12 years. We hope this guide will encourage research communities to annotate gene products of their interest to enhance the corpus of GO annotations available to all. DATABASE URL: http://www.geneontology.org.
dc.format.mediumElectronic-Print
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBiological Phenomena
dc.subjectSequence Homology, Nucleic Acid
dc.subjectDecision Trees
dc.subjectReference Standards
dc.subjectData Mining
dc.subjectMolecular Sequence Annotation
dc.titleA guide to best practices for Gene Ontology (GO) manual annotation.
dc.typeArticle
prism.publicationDate2013
prism.publicationNameDatabase (Oxford)
prism.startingPagebat054
prism.volume2013
dc.identifier.doi10.17863/CAM.30729
rioxxterms.versionofrecord10.1093/database/bat054
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2013-01
dc.contributor.orcidHarris, Midori [0000-0003-4148-4606]
dc.identifier.eissn1758-0463
rioxxterms.typeJournal Article/Review
cam.issuedOnline2013-07-09


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International