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dc.contributor.authorPerry, John
dc.contributor.authorDay, Felix
dc.date.accessioned2018-10-15T09:38:49Z
dc.date.available2018-10-15T09:38:49Z
dc.date.issued2018-09
dc.identifier.issn1097-6256
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/283624
dc.description.abstractAbstract Cannabis use is a heritable trait that has been associated with adverse mental health outcomes. In the largest genome-wide association study for lifetime cannabis use to date (N=184,765), we identified 8 genome-wide significant independent single nucleotide polymorphisms in 6 regions. All measured genetic variants combined explained 11% of the variance. Gene-based tests revealed 35 significant genes in 16 regions, and S-PrediXcan analyses showed that 21 genes had different expression levels for cannabis users versus non-users. The strongest finding across the different analyses was CADM2, which has been associated with substance use and risk-taking. Significant genetic correlations were found with 14 of 25 tested substance use and mental health traits, including smoking, alcohol use, schizophrenia, and risk-taking. Mendelian randomization analysis showed evidence for a causal positive influence of schizophrenia risk on cannabis use. Overall, our study gives new insights about the etiology of cannabis use and its relation with mental health.
dc.languageeng
dc.publisherSpringer Nature
dc.titleGWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia
dc.typeArticle
prism.endingPage1170
prism.publicationNameNature Neuroscience
prism.startingPage1160
prism.volume21
dc.identifier.doi10.17863/CAM.30994
dcterms.dateAccepted2018-07-10
rioxxterms.versionofrecord10.1038/s41593-018-0206-1
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-07-10
dc.contributor.orcidPerry, John [0000-0001-6483-3771]
dc.contributor.orcidDay, Felix [0000-0003-3789-7651]
dc.identifier.eissn1546-1726
dc.publisher.urlhttps://www.nature.com/articles/s41593-018-0206-1#Sec1
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MC_UU_12015/2)
cam.issuedOnline2018-08-27
dc.identifier.urlhttps://www.nature.com/articles/s41593-018-0206-1#Sec1
rioxxterms.freetoread.startdate2019-02-27


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