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dc.contributor.authorMalkemper, E Pascal
dc.contributor.authorMason, Matthew J
dc.contributor.authorKagerbauer, Daniel
dc.contributor.authorNimpf, Simon
dc.contributor.authorKeays, David A
dc.date.accessioned2018-11-01T14:03:48Z
dc.date.available2018-11-01T14:03:48Z
dc.date.issued2018-08-02
dc.identifier.issn2046-6390
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/284529
dc.description.abstractThe vertebrate inner ear contains vestibular receptors with dense crystals of calcium carbonate, the otoconia. The production and maintenance of otoconia is a delicate process, the perturbation of which can lead to severe vestibular dysfunction in humans. The details of these processes are not well understood. Here, we report the discovery of a new otoconial mass in the lagena of adult pigeons that was present in more than 70% of birds. Based on histological, tomographic and elemental analyses, we conclude that the structure likely represents an ectopically-formed otoconial assembly. Given its frequent natural occurrence, we suggest that the pigeon lagena is a valuable model system for investigating misregulated otoconial formation.This article has an associated First Person interview with the first author of the paper.
dc.description.sponsorshipEuropean Research Council [336725 to D.A.K.]; Austrian Science Fund [Y726 to D.A.K.]; Diamond Light Source [project no. MT16522]
dc.format.mediumElectronic
dc.languageeng
dc.publisherThe Company of Biologists
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleEctopic otoconial formation in the lagena of the pigeon inner ear.
dc.typeArticle
prism.issueIdentifier8
prism.publicationDate2018
prism.publicationNameBiol Open
prism.volume7
dc.identifier.doi10.17863/CAM.31904
dcterms.dateAccepted2018-06-20
rioxxterms.versionofrecord10.1242/bio.034462
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-08-02
dc.contributor.orcidMalkemper, E Pascal [0000-0003-1099-0119]
dc.contributor.orcidMason, Matthew J [0000-0001-7845-0720]
dc.contributor.orcidKeays, David A [0000-0002-8343-8002]
dc.identifier.eissn2046-6390
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-08-02


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International