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dc.contributor.authorJalal, Baland
dc.contributor.authorBruehl, Annette
dc.contributor.authorO'Callaghan, Claire
dc.contributor.authorPiercy, Thomas
dc.contributor.authorCardinal, Rudolf
dc.contributor.authorRamachandran, Vilayanur S
dc.contributor.authorSahakian, Barbara
dc.date.accessioned2018-11-02T11:39:26Z
dc.date.available2018-11-02T11:39:26Z
dc.date.issued2018-10-23
dc.identifier.issn2045-2322
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/284555
dc.description.abstractOne type of obsessive-compulsive disorder (OCD) is characterized by contamination fears and compulsive cleansing. Few effective treatments are available for this debilitating condition. Compulsive symptoms, such as excessive washing, are believed to be mediated by cognitive inflexibility-arguably the most striking cognitive impairment in OCD. In this study, we investigated the effects of two novel smartphone interventions on cognitive flexibility and OCD symptoms in healthy individuals with OCD-like contamination fears. In the first intervention, participants watched a brief video recording of themselves engaging in handwashing on a smartphone, four times a day, for a total of one week (N = 31). The second intervention was similar except that participants watched themselves repeatedly touching a disgust-inducing object (N = 31). In a third (control) "intervention", participants watched themselves performing sequential hand movements (N = 31). As hypothesized, the two smartphone interventions, unlike the control, improved cognitive flexibility; as assessed on the Intradimensional-Extradimensional Set Shifting task (a sensitive marker of cognitive flexibility). The two interventions, unlike the control, also improved OCD symptoms (measured with the Obsessive-Compulsive Inventory-Revised and Yale-Brown Obsessive-Compulsive Scale). Finally, we found high levels of adherence to the interventions. These findings have significant clinical implications for OCD.
dc.format.mediumElectronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHumans
dc.subjectFear
dc.subjectCognition
dc.subjectObsessive-Compulsive Disorder
dc.subjectNeuropsychological Tests
dc.subjectAdolescent
dc.subjectAdult
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectMobile Applications
dc.subjectSmartphone
dc.titleNovel Smartphone Interventions Improve Cognitive Flexibility and Obsessive-Compulsive Disorder Symptoms in Individuals with Contamination Fears.
dc.typeArticle
prism.issueIdentifier1
prism.publicationDate2018
prism.publicationNameSci Rep
prism.startingPage14923
prism.volume8
dc.identifier.doi10.17863/CAM.31930
dcterms.dateAccepted2018-09-14
rioxxterms.versionofrecord10.1038/s41598-018-33142-2
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-10-23
dc.contributor.orcidBruehl, Annette [0000-0003-4704-4986]
dc.contributor.orcidO'Callaghan, Claire [0000-0001-5698-6364]
dc.contributor.orcidCardinal, Rudolf [0000-0002-8751-5167]
dc.contributor.orcidSahakian, Barbara [0000-0001-7352-1745]
dc.identifier.eissn2045-2322
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (G1000183)
pubs.funder-project-idMedical Research Council (MC_PC_17213)
cam.issuedOnline2018-10-23


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International