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dc.contributor.authorJenkins, Timothyen
dc.contributor.authorPeachey, Laura Een
dc.contributor.authorAjami, Nadim Jen
dc.contributor.authorMacDonald, Andrew Sen
dc.contributor.authorHsieh, Michael Hen
dc.contributor.authorBrindley, Paul Jen
dc.contributor.authorCantacessi, Cinziaen
dc.contributor.authorRinaldi, Gabrielen
dc.date.accessioned2018-11-05T10:25:46Z
dc.date.available2018-11-05T10:25:46Z
dc.date.issued2018-08-13en
dc.identifier.issn2045-2322
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/284599
dc.description.abstractIn spite of the extensive contribution of intestinal pathology to the pathophysiology of schistosomiasis, little is known of the impact of schistosome infection on the composition of the gut commensal microbiota of its mammalian host. Here, we characterised the fluctuations in the composition of the gut microbial flora of the small and large intestine, as well as the changes in abundance of individual microbial species, of mice experimentally infected with Schistosoma mansoni with the goal of identifying microbial taxa with potential roles in the pathophysiology of infection and disease. Bioinformatic analyses of bacterial 16SrRNA gene data revealed an overall reduction in gut microbial alpha diversity, alongside a significant increase in microbial beta diversity characterised by expanded populations of Akkermansia muciniphila (phylum Verrucomicrobia) and lactobacilli, in the gut microbiota of S. mansoni-infected mice when compared to uninfected control animals. These data support a role of the mammalian gut microbiota in the pathogenesis of hepato-intestinal schistosomiasis and serves as a foundation for the design of mechanistic studies to unravel the complex relationships amongst parasitic helminths, gut commensal microbiota, pathophysiology of infection and host immunity.
dc.format.mediumElectronicen
dc.languageengen
dc.publisherNature Publishing Group
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectIntestinesen
dc.subjectAnimalsen
dc.subjectHumansen
dc.subjectMiceen
dc.subjectSchistosoma mansonien
dc.subjectBacteroidesen
dc.subjectLactobacillusen
dc.subjectSchistosomiasis mansonien
dc.subjectDisease Models, Animalen
dc.subjectDNA, Bacterialen
dc.subjectRNA, Ribosomal, 16Sen
dc.subjectFemaleen
dc.subjectVerrucomicrobiaen
dc.subjectGastrointestinal Microbiomeen
dc.titleSchistosoma mansoni infection is associated with quantitative and qualitative modifications of the mammalian intestinal microbiota.en
dc.typeArticle
prism.issueIdentifier1en
prism.publicationDate2018en
prism.publicationNameScientific reportsen
prism.startingPage12072
prism.volume8en
dc.identifier.doi10.17863/CAM.31973
dcterms.dateAccepted2018-07-20en
rioxxterms.versionofrecord10.1038/s41598-018-30412-xen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-08-13en
dc.contributor.orcidJenkins, Timothy [0000-0003-2979-5663]
dc.contributor.orcidAjami, Nadim J [0000-0002-3808-8576]
dc.contributor.orcidMacDonald, Andrew S [0000-0002-5356-1149]
dc.contributor.orcidBrindley, Paul J [0000-0003-1765-0002]
dc.contributor.orcidCantacessi, Cinzia [0000-0001-6863-2950]
dc.identifier.eissn2045-2322
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBBSRC (1643688)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International