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dc.contributor.authorJenkins, Timothy
dc.contributor.authorPeachey, Laura E
dc.contributor.authorAjami, Nadim J
dc.contributor.authorMacDonald, Andrew S
dc.contributor.authorHsieh, Michael H
dc.contributor.authorBrindley, Paul J
dc.contributor.authorCantacessi, Cinzia
dc.contributor.authorRinaldi, Gabriel
dc.date.accessioned2018-11-05T10:25:46Z
dc.date.available2018-11-05T10:25:46Z
dc.date.issued2018-08-13
dc.identifier.issn2045-2322
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/284599
dc.description.abstractIn spite of the extensive contribution of intestinal pathology to the pathophysiology of schistosomiasis, little is known of the impact of schistosome infection on the composition of the gut microbiota of its mammalian host. Here, we characterised the fluctuations in the composition of the gut microbial flora of the small and large intestine, as well as the changes in abundance of individual microbial species, of mice experimentally infected with Schistosoma mansoni with the goal of identifying microbial taxa with potential roles in the pathophysiology of infection and disease. Bioinformatic analyses of bacterial 16S rRNA gene data revealed an overall reduction in gut microbial alpha diversity, alongside a significant increase in microbial beta diversity characterised by expanded populations of Akkermansia muciniphila (phylum Verrucomicrobia) and lactobacilli, in the gut microbiota of S. mansoni-infected mice when compared to uninfected control animals. These data support a role of the mammalian gut microbiota in the pathogenesis of hepato-intestinal schistosomiasis and serves as a foundation for the design of mechanistic studies to unravel the complex relationships amongst parasitic helminths, gut microbiota, pathophysiology of infection and host immunity.
dc.format.mediumElectronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectIntestines
dc.subjectAnimals
dc.subjectHumans
dc.subjectMice
dc.subjectSchistosoma mansoni
dc.subjectBacteroides
dc.subjectLactobacillus
dc.subjectSchistosomiasis mansoni
dc.subjectDisease Models, Animal
dc.subjectDNA, Bacterial
dc.subjectRNA, Ribosomal, 16S
dc.subjectFemale
dc.subjectVerrucomicrobia
dc.subjectGastrointestinal Microbiome
dc.titleSchistosoma mansoni infection is associated with quantitative and qualitative modifications of the mammalian intestinal microbiota.
dc.typeArticle
prism.issueIdentifier1
prism.publicationDate2018
prism.publicationNameSci Rep
prism.startingPage12072
prism.volume8
dc.identifier.doi10.17863/CAM.31973
dcterms.dateAccepted2018-07-20
rioxxterms.versionofrecord10.1038/s41598-018-30412-x
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-08-13
dc.contributor.orcidJenkins, Timothy [0000-0003-2979-5663]
dc.contributor.orcidAjami, Nadim J [0000-0002-3808-8576]
dc.contributor.orcidMacDonald, Andrew S [0000-0002-5356-1149]
dc.contributor.orcidCantacessi, Cinzia [0000-0001-6863-2950]
dc.identifier.eissn2045-2322
rioxxterms.typeJournal Article/Review
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (1643688)
cam.issuedOnline2018-08-13


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International