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dc.contributor.authorSelby, Nicholas M
dc.contributor.authorBlankestijn, Peter J
dc.contributor.authorBoor, Peter
dc.contributor.authorCombe, Christian
dc.contributor.authorEckardt, Kai-Uwe
dc.contributor.authorEikefjord, Eli
dc.contributor.authorGarcia-Fernandez, Nuria
dc.contributor.authorGolay, Xavier
dc.contributor.authorGordon, Isky
dc.contributor.authorGrenier, Nicolas
dc.contributor.authorHockings, Paul D
dc.contributor.authorJensen, Jens D
dc.contributor.authorJoles, Jaap A
dc.contributor.authorKalra, Philip A
dc.contributor.authorKrämer, Bernhard K
dc.contributor.authorMark, Patrick B
dc.contributor.authorMendichovszky, Iosif
dc.contributor.authorNikolic, Olivera
dc.contributor.authorOdudu, Aghogho
dc.contributor.authorOng, Albert CM
dc.contributor.authorOrtiz, Alberto
dc.contributor.authorPruijm, Menno
dc.contributor.authorRemuzzi, Giuseppe
dc.contributor.authorRørvik, Jarle
dc.contributor.authorde Seigneux, Sophie
dc.contributor.authorSimms, Roslyn J
dc.contributor.authorSlatinska, Janka
dc.contributor.authorSummers, Paul
dc.contributor.authorTaal, Maarten W
dc.contributor.authorThoeny, Harriet C
dc.contributor.authorVallée, Jean-Paul
dc.contributor.authorWolf, Marcos
dc.contributor.authorCaroli, Anna
dc.contributor.authorSourbron, Steven
dc.date.accessioned2018-11-06T00:30:22Z
dc.date.available2018-11-06T00:30:22Z
dc.date.issued2018-09-01
dc.identifier.issn0931-0509
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/284642
dc.description.abstractFunctional renal magnetic resonance imaging (MRI) has seen a number of recent advances, and techniques are now available that can generate quantitative imaging biomarkers with the potential to improve the management of kidney disease. Such biomarkers are sensitive to changes in renal blood flow, tissue perfusion, oxygenation and microstructure (including inflammation and fibrosis), processes that are important in a range of renal diseases including chronic kidney disease. However, several challenges remain to move these techniques towards clinical adoption, from technical validation through biological and clinical validation, to demonstration of cost-effectiveness and regulatory qualification. To address these challenges, the European Cooperation in Science and Technology Action PARENCHIMA was initiated in early 2017. PARENCHIMA is a multidisciplinary pan-European network with an overarching aim of eliminating the main barriers to the broader evaluation, commercial exploitation and clinical use of renal MRI biomarkers. This position paper lays out PARENCHIMA's vision on key clinical questions that MRI must address to become more widely used in patients with kidney disease, first within research settings and ultimately in clinical practice. We then present a series of practical recommendations to accelerate the study and translation of these techniques.
dc.description.sponsorshipEU COST Action PARENCHIMA
dc.format.mediumPrint
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectHumans
dc.subjectDisease Progression
dc.subjectMagnetic Resonance Imaging
dc.subjectRenal Insufficiency, Chronic
dc.subjectBiomarkers
dc.titleMagnetic resonance imaging biomarkers for chronic kidney disease: a position paper from the European Cooperation in Science and Technology Action PARENCHIMA.
dc.typeArticle
prism.endingPageii14
prism.issueIdentifiersuppl_2
prism.publicationDate2018
prism.publicationNameNephrol Dial Transplant
prism.startingPageii4
prism.volume33
dc.identifier.doi10.17863/CAM.32016
dcterms.dateAccepted2018-04-27
rioxxterms.versionofrecord10.1093/ndt/gfy152
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-09
dc.contributor.orcidMendichovszky, Iosif [0000-0002-3777-2827]
dc.identifier.eissn1460-2385
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-08-23


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Attribution-NonCommercial 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial 4.0 International