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dc.contributor.authorBoland, Barry
dc.contributor.authorYu, Wai Haung
dc.contributor.authorCorti, Olga
dc.contributor.authorMollereau, Bertrand
dc.contributor.authorHenriques, Alexandre
dc.contributor.authorBezard, Erwan
dc.contributor.authorPastores, Greg M
dc.contributor.authorRubinsztein, David
dc.contributor.authorNixon, Ralph A
dc.contributor.authorDuchen, Michael R
dc.contributor.authorMallucci, Giovanna
dc.contributor.authorKroemer, Guido
dc.contributor.authorLevine, Beth
dc.contributor.authorEskelinen, Eeva-Liisa
dc.contributor.authorMochel, Fanny
dc.contributor.authorSpedding, Michael
dc.contributor.authorLouis, Caroline
dc.contributor.authorMartin, Olivier R
dc.contributor.authorMillan, Mark J
dc.date.accessioned2018-11-14T00:30:29Z
dc.date.available2018-11-14T00:30:29Z
dc.date.issued2018-09
dc.identifier.issn1474-1776
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285020
dc.description.abstractNeurodegenerative disorders of ageing (NDAs) such as Alzheimer disease, Parkinson disease, frontotemporal dementia, Huntington disease and amyotrophic lateral sclerosis represent a major socio-economic challenge in view of their high prevalence yet poor treatment. They are often called 'proteinopathies' owing to the presence of misfolded and aggregated proteins that lose their physiological roles and acquire neurotoxic properties. One reason underlying the accumulation and spread of oligomeric forms of neurotoxic proteins is insufficient clearance by the autophagic-lysosomal network. Several other clearance pathways are also compromised in NDAs: chaperone-mediated autophagy, the ubiquitin-proteasome system, extracellular clearance by proteases and extrusion into the circulation via the blood-brain barrier and glymphatic system. This article focuses on emerging mechanisms for promoting the clearance of neurotoxic proteins, a strategy that may curtail the onset and slow the progression of NDAs.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.subjectAnimals
dc.subjectHumans
dc.subjectNeurodegenerative Diseases
dc.subjectProteasome Endopeptidase Complex
dc.subjectUbiquitin
dc.subjectNeurotoxins
dc.subjectAging
dc.subjectAutophagy
dc.titlePromoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing.
dc.typeArticle
prism.endingPage688
prism.issueIdentifier9
prism.publicationDate2018
prism.publicationNameNat Rev Drug Discov
prism.startingPage660
prism.volume17
dc.identifier.doi10.17863/CAM.32390
dcterms.dateAccepted2018-05-24
rioxxterms.versionofrecord10.1038/nrd.2018.109
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-09
dc.contributor.orcidRubinsztein, David [0000-0001-5002-5263]
dc.contributor.orcidMallucci, Giovanna [0000-0001-8504-1191]
dc.identifier.eissn1474-1784
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-08-17
rioxxterms.freetoread.startdate2019-09-30


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