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dc.contributor.authorSmyth, Redmond P
dc.contributor.authorNegroni, Matteo
dc.contributor.authorLever, Andrew
dc.contributor.authorMak, Johnson
dc.contributor.authorKenyon, Julia
dc.date.accessioned2018-11-16T00:31:24Z
dc.date.available2018-11-16T00:31:24Z
dc.date.issued2018
dc.identifier.issn1664-3224
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285154
dc.description.abstractThe central dogma of molecular biology describes the flow of genetic information from DNA to protein via an RNA intermediate. For many years, RNA has been considered simply as a messenger relaying information between DNA and proteins. Recent advances in next generation sequencing technology, bioinformatics, and non-coding RNA biology have highlighted the many important roles of RNA in virtually every biological process. Our understanding of RNA biology has been further enriched by a number of significant advances in probing RNA structures. It is now appreciated that many cellular and viral biological processes are highly dependent on specific RNA structures and/or sequences, and such reliance will undoubtedly impact on the evolution of both hosts and viruses. As a contribution to this special issue on host immunity and virus evolution, it is timely to consider how RNA sequences and structures could directly influence the co-evolution between hosts and viruses. In this manuscript, we begin by stating some of the basic principles of RNA structures, followed by describing some of the critical RNA structures in both viruses and hosts. More importantly, we highlight a number of available new tools to predict and to evaluate novel RNA structures, pointing out some of the limitations readers should be aware of in their own analyses.
dc.description.sponsorshipThis work was supported by the Helmholtz Association (VH-NG-1347 to RS), Sidaction (AI25-1-02335 to MN), The Biomedical Research Centre UK and Clinical Academic Reserve UK (to AL), and the Medical Research Council UK (MR/N022939/1 to AL and JK). JM is recipient of funding from Australian National Health and Medical Research Council project grant App1121697.
dc.format.mediumElectronic-eCollection
dc.languageeng
dc.publisherFrontiers Media SA
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAnimals
dc.subjectHumans
dc.subjectViruses
dc.subjectVirus Diseases
dc.subjectRNA
dc.subjectEvolution, Molecular
dc.subjectVirulence
dc.subjectBase Sequence
dc.subjectNucleic Acid Conformation
dc.subjectHost-Pathogen Interactions
dc.titleRNA Structure-A Neglected Puppet Master for the Evolution of Virus and Host Immunity.
dc.typeArticle
prism.publicationDate2018
prism.publicationNameFront Immunol
prism.startingPage2097
prism.volume9
dc.identifier.doi10.17863/CAM.32524
dcterms.dateAccepted2018-08-24
rioxxterms.versionofrecord10.3389/fimmu.2018.02097
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-01
dc.contributor.orcidKenyon, Julia [0000-0001-6055-7052]
dc.identifier.eissn1664-3224
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/N022939/1)
pubs.funder-project-idMedical Research Council (G0801709)
cam.issuedOnline2018-09-19


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International