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dc.contributor.authorPalittapongarnpim, Prasit
dc.contributor.authorAjawatanawong, Pravech
dc.contributor.authorViratyosin, Wasna
dc.contributor.authorSmittipat, Nat
dc.contributor.authorDisratthakit, Areeya
dc.contributor.authorMahasirimongkol, Surakameth
dc.contributor.authorYanai, Hideki
dc.contributor.authorYamada, Norio
dc.contributor.authorNedsuwan, Supalert
dc.contributor.authorImasanguan, Worarat
dc.contributor.authorKantipong, Pacharee
dc.contributor.authorChaiyasirinroje, Boonchai
dc.contributor.authorWongyai, Jiraporn
dc.contributor.authorToyo-Oka, Licht
dc.contributor.authorPhelan, Jody
dc.contributor.authorParkhill, Julian
dc.contributor.authorClark, Taane G
dc.contributor.authorHibberd, Martin L
dc.contributor.authorRuengchai, Wuthiwat
dc.contributor.authorPalittapongarnpim, Panawun
dc.contributor.authorJuthayothin, Tada
dc.contributor.authorTongsima, Sissades
dc.contributor.authorTokunaga, Katsushi
dc.date.accessioned2018-11-23T00:31:59Z
dc.date.available2018-11-23T00:31:59Z
dc.date.issued2018-08-02
dc.identifier.issn2045-2322
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285801
dc.description.abstractTuberculosis presents a global health challenge. Mycobacterium tuberculosis is divided into several lineages, each with a different geographical distribution. M. tuberculosis lineage 1 (L1) is common in the high-burden areas in East Africa and Southeast Asia. Although the founder effect contributes significantly to the phylogeographic profile, co-evolution between the host and M. tuberculosis may also play a role. Here, we reported the genomic analysis of 480 L1 isolates from patients in northern Thailand. The studied bacterial population was genetically diverse, allowing the identification of a total of 18 sublineages distributed into three major clades. The majority of isolates belonged to L1.1 followed by L1.2.1 and L1.2.2. Comparison of the single nucleotide variant (SNV) phylogenetic tree and the clades defined by spoligotyping revealed some monophyletic clades representing EAI2_MNL, EAI2_NTM and EAI6_BGD1 spoligotypes. Our work demonstrates that ambiguity in spoligotype assignment could be partially resolved if the entire DR region is investigated. Using the information to map L1 diversity across Southeast Asia highlighted differences in the dominant strain-types in each individual country, despite extensive interactions between populations over time. This finding supported the hypothesis that there is co-evolution between the bacteria and the host, and have implications for tuberculosis disease control.
dc.format.mediumElectronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHumans
dc.subjectMycobacterium tuberculosis
dc.subjectEvolution, Molecular
dc.subjectGenome, Bacterial
dc.subjectThailand
dc.subjectFemale
dc.subjectMale
dc.subjectHost-Pathogen Interactions
dc.subjectWhole Genome Sequencing
dc.titleEvidence for Host-Bacterial Co-evolution via Genome Sequence Analysis of 480 Thai Mycobacterium tuberculosis Lineage 1 Isolates.
dc.typeArticle
prism.issueIdentifier1
prism.publicationDate2018
prism.publicationNameSci Rep
prism.startingPage11597
prism.volume8
dc.identifier.doi10.17863/CAM.33145
dcterms.dateAccepted2018-07-20
rioxxterms.versionofrecord10.1038/s41598-018-29986-3
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-08-02
dc.contributor.orcidToyo-Oka, Licht [0000-0002-9738-2441]
dc.contributor.orcidPhelan, Jody [0000-0001-8323-7019]
dc.contributor.orcidParkhill, Julian [0000-0002-7069-5958]
dc.contributor.orcidClark, Taane G [0000-0001-8985-9265]
dc.contributor.orcidTongsima, Sissades [0000-0002-1491-1839]
dc.identifier.eissn2045-2322
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-08-02


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International