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dc.contributor.authorTovey, Corinne A
dc.contributor.authorConduit, Paul
dc.date.accessioned2018-12-04T00:30:14Z
dc.date.available2018-12-04T00:30:14Z
dc.date.issued2018-12-07
dc.identifier.issn0071-1365
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286233
dc.description.abstractIn this short review, we give an overview of microtubule nucleation within cells. It is nearly 30 years since the discovery of γ-tubulin, a member of the tubulin superfamily essential for proper microtubule nucleation in all eukaryotes. γ-tubulin associates with other proteins to form multiprotein γ-tubulin ring complexes (γ-TuRCs) that template and catalyse the otherwise kinetically unfavourable assembly of microtubule filaments. These filaments can be dynamic or stable and they perform diverse functions, such as chromosome separation during mitosis and intracellular transport in neurons. The field has come a long way in understanding γ-TuRC biology but several important and unanswered questions remain, and we are still far from understanding the regulation of microtubule nucleation in a multicellular context. Here, we review the current literature on γ-TuRC assembly, recruitment, and activation and discuss the potential importance of γ-TuRC heterogeneity, the role of non-γ-TuRC proteins in microtubule nucleation, and whether γ-TuRCs could serve as good drug targets for cancer therapy.
dc.description.sponsorshipWellcome Trust and Royal Society (105653/Z/14/Z) BBSRC BB/M011194/1
dc.format.mediumElectronic-Print
dc.languageeng
dc.publisherPortland Press Ltd.
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectMicrotubules
dc.subjectAnimals
dc.subjectHumans
dc.subjectTubulin
dc.subjectMicrotubule-Associated Proteins
dc.subjectModels, Biological
dc.titleMicrotubule nucleation by γ-tubulin complexes and beyond.
dc.typeArticle
prism.endingPage780
prism.issueIdentifier6
prism.publicationDate2018
prism.publicationNameEssays Biochem
prism.startingPage765
prism.volume62
dc.identifier.doi10.17863/CAM.33546
dcterms.dateAccepted2018-09-13
rioxxterms.versionofrecord10.1042/EBC20180028
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-12-07
dc.contributor.orcidConduit, Paul [0000-0002-7822-1191]
dc.identifier.eissn1744-1358
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (105653/Z/14/Z)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/M011194/1)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (1644191)
cam.issuedOnline2018-10-12


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International