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dc.contributor.authorPreissler, Steffen
dc.contributor.authorRon, David
dc.date.accessioned2018-12-04T00:31:00Z
dc.date.available2018-12-04T00:31:00Z
dc.date.issued2019-04-01
dc.identifier.issn1943-0264
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286260
dc.description.abstractThe physiological consequences of the unfolded protein response (UPR) are mediated by changes in gene expression. Underlying them are rapid processes involving preexisting components. We review recent insights gained into the regulation of the endoplasmic reticulum (ER) Hsp70 chaperone BiP, whose incorporation into inactive oligomers and reversible AMPylation and de-AMPylation present a first line of response to fluctuating levels of unfolded proteins. BiP activity is tied to the regulation of the UPR transducers by a recently discovered cycle of ER-localized, J protein-mediated formation of a repressive IRE1-BiP complex, whose working we contrast to an alternative model for UPR regulation that relies on direct recognition of unfolded proteins. We conclude with a discussion of mechanisms that repress messenger RNA (mRNA) translation to limit the flux of newly synthesized proteins into the ER, a rapid adaptation that does not rely on new macromolecule biosynthesis.
dc.description.sponsorshipWellcome Trust
dc.format.mediumElectronic
dc.languageeng
dc.publisherCold Spring Harbor Laboratory
dc.subjectEndoplasmic Reticulum
dc.subjectHeat-Shock Proteins
dc.subjectProtein Biosynthesis
dc.subjectProtein Processing, Post-Translational
dc.subjectUnfolded Protein Response
dc.titleEarly Events in the Endoplasmic Reticulum Unfolded Protein Response.
dc.typeArticle
prism.issueIdentifier4
prism.publicationDate2019
prism.publicationNameCold Spring Harb Perspect Biol
prism.volume11
dc.identifier.doi10.17863/CAM.33572
dcterms.dateAccepted2018-09-25
rioxxterms.versionofrecord10.1101/cshperspect.a033894
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-04
dc.contributor.orcidPreissler, Steffen [0000-0001-7936-9836]
dc.contributor.orcidRon, David [0000-0002-3014-5636]
dc.identifier.eissn1943-0264
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (200848/Z/16/Z)
pubs.funder-project-idWellcome Trust (100140/Z/12/Z)
cam.issuedOnline2019-04
rioxxterms.freetoread.startdate2019-11-05


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