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dc.contributor.authorKarimi, Ayesha
dc.contributor.authorHopes, Marina
dc.contributor.authorMartin, Keith
dc.contributor.authorLindfield, Dan
dc.date.accessioned2018-12-13T00:32:15Z
dc.date.available2018-12-13T00:32:15Z
dc.date.issued2018-10
dc.identifier.issn1057-0829
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286830
dc.description.abstractAIMS: To assess the efficacy and safety of the Xen gel stent in reducing intraocular pressure (IOP) in eyes with prior failed trabeculectomy and to determine the frequency of complications and further intervention. METHODS: Retrospective case note review of all patients with prior trabeculectomy undergoing Xen surgery across 5 centers from August 2015 to May 2017. RESULTS: In total, 17 surgeries were reviewed. IOP reduced from 21.5 (±2.4) mm Hg preoperatively to 13.6 (±3.4) mm Hg at month 12 (P<0.05). Medication usage reduced from 2.8 (±0.6) preoperatively to 1.0 (±1.3) at month 12 (P<0.05). Adverse events included: numerical hypotony (IOP<6 mm Hg) in 4 cases (23.5%) that all resolved spontaneously, IOP spike of ≥30 mm Hg in 2 (11.8%) cases and transient occlusion of the implant by iris in 1 (5.9%) case. Secondary filtration surgery (Baerveldt tube implantation) was required in 2 (11.8%) cases. Postoperative bleb intervention was required in 9 cases (52.9%), usually in the first month after surgery. CONCLUSIONS: Xen reduces IOP and number of medications in eyes with failed trabeculectomy. Detailed preoperative conjunctival assessment and targeted stent placement is required. Prospective data and follow-up beyond 12 months are required but Xen seems a viable, effective, and safe option after failed trabeculectomy.
dc.format.mediumPrint
dc.languageeng
dc.publisherOvid Technologies (Wolters Kluwer Health)
dc.subjectHumans
dc.subjectOcular Hypertension
dc.subjectFiltering Surgery
dc.subjectTrabeculectomy
dc.subjectRetrospective Studies
dc.subjectGlaucoma Drainage Implants
dc.subjectStents
dc.subjectIntraocular Pressure
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.titleEfficacy and Safety of the Ab-interno Xen Gel Stent After Failed Trabeculectomy.
dc.typeArticle
prism.endingPage868
prism.issueIdentifier10
prism.publicationDate2018
prism.publicationNameJ Glaucoma
prism.startingPage864
prism.volume27
dc.identifier.doi10.17863/CAM.34137
rioxxterms.versionofrecord10.1097/IJG.0000000000001044
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-10
dc.contributor.orcidMartin, Keith [0000-0002-9347-3661]
dc.identifier.eissn1536-481X
rioxxterms.typeJournal Article/Review
rioxxterms.freetoread.startdate2019-10-31


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