Show simple item record

dc.contributor.authorTaylor, CW
dc.contributor.authorThillaiappan, N
dc.contributor.authorHasan, Gaiti
dc.contributor.authorPragnya, Chakraborty
dc.date.accessioned2018-12-13T00:33:06Z
dc.date.available2018-12-13T00:33:06Z
dc.date.issued2019-07
dc.identifier.issn0167-4889
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286861
dc.description.abstractInositol 1,4,5-trisphosphate receptors (IP3R) are the most widely expressed intracellular Ca2+ release channels. Their activation by IP3 and Ca2+ allows Ca2+ to pass rapidly from the ER lumen to the cytosol. The resulting increase in cytosolic [Ca2+] may directly regulate cytosolic effectors or fuel Ca2+ uptake by other organelles, while the decrease in ER luminal [Ca2+] stimulates store-operated Ca2+ entry (SOCE). We are close to understanding the structural basis of both IP3R activation, and the interactions between the ER Ca2+-sensor, STIM, and the plasma membrane Ca2+ channel, Orai, that lead to SOCE. IP3Rs are the usual means through which extracellular stimuli, through ER Ca2+ release, stimulate SOCE. Here, we review evidence that the IP3Rs most likely to respond to IP3 are optimally placed to allow regulation of SOCE. We also consider evidence that IP3Rs may regulate SOCE downstream of their ability to deplete ER Ca2+ stores. Finally, we review evidence that IP3Rs in the plasma membrane can also directly mediate Ca2+ entry in some cells.
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleIP3 receptors and Ca2+ entry
dc.typeArticle
prism.publicationNameBiochimica et Biophysica Acta
dc.identifier.doi10.17863/CAM.34167
dcterms.dateAccepted2018-11-08
rioxxterms.versionofrecord10.1016/j.bbamcr.2018.11.007
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-11-08
dc.contributor.orcidTaylor, Colin [0000-0001-7771-1044]
dc.contributor.orcidThillaiappan, Nagendra Babu [0000-0001-5641-4067]
dc.identifier.eissn1879-2596
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (101844/Z/13/Z)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/P005330/1)
cam.issuedOnline2018-12-15
rioxxterms.freetoread.startdate2019-11-15


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International