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dc.contributor.authorElting, Jan Willem J
dc.contributor.authorTas, Jeanette
dc.contributor.authorAries, Marcel Jh
dc.contributor.authorCzosnyka, Marek
dc.contributor.authorMaurits, Natasha M
dc.date.accessioned2018-12-15T00:30:25Z
dc.date.available2018-12-15T00:30:25Z
dc.date.issued2020-01
dc.identifier.issn0271-678X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286983
dc.description.abstractWe analysed mean arterial blood pressure, cerebral blood flow velocity, oxygenated haemoglobin and deoxygenated haemoglobin signals to estimate dynamic cerebral autoregulation. We compared macrovascular (mean arterial blood pressure-cerebral blood flow velocity) and microvascular (oxygenated haemoglobin-deoxygenated haemoglobin) dynamic cerebral autoregulation estimates during three different conditions: rest, mild hypocapnia and hypercapnia. Microvascular dynamic cerebral autoregulation estimates were created by introducing the constant time lag plus constant phase shift model, which enables correction for transit time, blood flow and blood volume oscillations (TT-BF/BV correction). After TT-BF/BV correction, a significant agreement between mean arterial blood pressure-cerebral blood flow velocity and oxygenated haemoglobin-deoxygenated haemoglobin phase differences in the low frequency band was found during rest (left: intraclass correlation=0.6, median phase difference 29.5° vs. 30.7°, right: intraclass correlation=0.56, median phase difference 32.6° vs. 39.8°) and mild hypocapnia (left: intraclass correlation=0.73, median phase difference 48.6° vs. 43.3°, right: intraclass correlation=0.70, median phase difference 52.1° vs. 61.8°). During hypercapnia, the mean transit time decreased and blood volume oscillations became much more prominent, except for very low frequencies. The transit time related to blood flow oscillations was remarkably stable during all conditions. We conclude that non-invasive microvascular dynamic cerebral autoregulation estimates are similar to macrovascular dynamic cerebral autoregulation estimates, after TT-BF/BV correction is applied. These findings may increase the feasibility of non-invasive continuous autoregulation monitoring and guided therapy in clinical situations.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherSAGE Publications
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectHumans
dc.subjectHypercapnia
dc.subjectHypocapnia
dc.subjectOxyhemoglobins
dc.subjectUltrasonography, Doppler, Transcranial
dc.subjectSpectroscopy, Near-Infrared
dc.subjectBlood Flow Velocity
dc.subjectHomeostasis
dc.subjectBlood Volume
dc.subjectBlood Pressure
dc.subjectCerebrovascular Circulation
dc.subjectRest
dc.subjectAdult
dc.subjectFemale
dc.subjectMale
dc.subjectHemodynamics
dc.titleDynamic cerebral autoregulation estimates derived from near infrared spectroscopy and transcranial Doppler are similar after correction for transit time and blood flow and blood volume oscillations.
dc.typeArticle
prism.endingPage149
prism.issueIdentifier1
prism.publicationDate2020
prism.publicationNameJ Cereb Blood Flow Metab
prism.startingPage135
prism.volume40
dc.identifier.doi10.17863/CAM.34292
rioxxterms.versionofrecord10.1177/0271678X18806107
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2020-01
dc.contributor.orcidCzosnyka, Marek [0000-0003-2446-8006]
dc.identifier.eissn1559-7016
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-10-24


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Attribution-NonCommercial 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial 4.0 International