Show simple item record

dc.contributor.authorGrydeland, Håkon
dc.contributor.authorVertes, Petra
dc.contributor.authorVáša, František
dc.contributor.authorRomero-Garcia, Rafael
dc.contributor.authorWhitaker, Kirstie
dc.contributor.authorAlexander-Bloch, Aaron F
dc.contributor.authorBjørnerud, Atle
dc.contributor.authorPatel, Ameera X
dc.contributor.authorSederevicius, Donatas
dc.contributor.authorTamnes, Christian K
dc.contributor.authorWestlye, Lars T
dc.contributor.authorWhite, Simon
dc.contributor.authorWalhovd, Kristine B
dc.contributor.authorFjell, Anders M
dc.contributor.authorBullmore, Edward
dc.date.accessioned2019-01-08T00:31:02Z
dc.date.available2019-01-08T00:31:02Z
dc.date.issued2019-03-01
dc.identifier.issn1047-3211
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/287608
dc.description.abstractSeminal human brain histology work has demonstrated developmental waves of myelination. Here, using a micro-structural magnetic resonance imaging (MRI) marker linked to myelin, we studied fine-grained age differences to deduce waves of growth, stability, and decline of cortical myelination over the life-cycle. In 484 participants, aged 8-85 years, we fitted smooth growth curves to T1- to T2-weighted ratio in each of 360 regions from one of seven cytoarchitectonic classes. From the first derivatives of these generally inverted-U trajectories, we defined three milestones: the age at peak growth; the age at onset of a stable plateau; and the age at the onset of decline. Age at peak growth had a bimodal distribution comprising an early (pre-pubertal) wave of primary sensory and motor cortices and a later (post-pubertal) wave of association, insular and limbic cortices. Most regions reached stability in the 30-s but there was a second wave reaching stability in the 50-s. Age at onset of decline was also bimodal: in some right hemisphere regions, the curve declined from the 60-s, but in other left hemisphere regions, there was no significant decline from the stable plateau. These results are consistent with regionally heterogeneous waves of intracortical myelinogenesis and age-related demyelination.
dc.description.sponsorshipThis work was supported by the Department of Psychology, University of Oslo (to K.B.W., A.M.F.); the Norwegian Research Council (to K.B.W., A.M.F.); and the European Research Council’s Starting/Consolidator Grant schemes (grant agreements 283634, 725025 (to A.M.F.) and 313440 (to K.B.W.)). P.E.V. was supported by the Medical Research Council (grant number MR/K020706/1) and is a Fellow of MQ: Transforming Mental Health (grant number MQF17_24). F.V. was supported by the Gates Cambridge Trust. K.W. is supported by a research fellowship at the Alan Turing Institute under the EPSRC (grant EP/N510129/1). S.R.W. was supported by the Medical Research Council, UK (Unit Programme number U105292687). This work was supported by the NIHR Cambridge Biomedical Research Centre.
dc.format.mediumPrint
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCerebral Cortex
dc.subjectMyelin Sheath
dc.subjectHumans
dc.subjectMagnetic Resonance Imaging
dc.subjectLongevity
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectChild
dc.subjectFemale
dc.subjectMale
dc.subjectYoung Adult
dc.subjectConnectome
dc.titleWaves of Maturation and Senescence in Micro-structural MRI Markers of Human Cortical Myelination over the Lifespan.
dc.typeArticle
prism.endingPage1381
prism.issueIdentifier3
prism.publicationDate2019
prism.publicationNameCereb Cortex
prism.startingPage1369
prism.volume29
dc.identifier.doi10.17863/CAM.34920
dcterms.dateAccepted2018-11-30
rioxxterms.versionofrecord10.1093/cercor/bhy330
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-03
dc.contributor.orcidVertes, Petra [0000-0002-0992-3210]
dc.contributor.orcidWhitaker, Kirstie [0000-0001-8498-4059]
dc.contributor.orcidWhite, Simon [0000-0001-8642-7037]
dc.contributor.orcidBullmore, Edward [0000-0002-8955-8283]
dc.identifier.eissn1460-2199
rioxxterms.typeJournal Article/Review
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
pubs.funder-project-idMRC (1185)
pubs.funder-project-idMQ: Transforming Mental Health (MQ17-24 Vertes)
pubs.funder-project-idMedical Research Council (MR/K020706/1)
pubs.funder-project-idMRC (unknown)
cam.issuedOnline2018-12-27


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International