Waves of Maturation and Senescence in Micro-structural MRI Markers of Human Cortical Myelination over the Lifespan.
dc.contributor.author | Grydeland, Håkon | |
dc.contributor.author | Vértes, Petra E | |
dc.contributor.author | Váša, František | |
dc.contributor.author | Romero-Garcia, Rafael | |
dc.contributor.author | Whitaker, Kirstie | |
dc.contributor.author | Alexander-Bloch, Aaron F | |
dc.contributor.author | Bjørnerud, Atle | |
dc.contributor.author | Patel, Ameera X | |
dc.contributor.author | Sederevicius, Donatas | |
dc.contributor.author | Tamnes, Christian K | |
dc.contributor.author | Westlye, Lars T | |
dc.contributor.author | White, Simon R | |
dc.contributor.author | Walhovd, Kristine B | |
dc.contributor.author | Fjell, Anders M | |
dc.contributor.author | Bullmore, Edward T | |
dc.date.accessioned | 2019-01-08T00:31:02Z | |
dc.date.available | 2019-01-08T00:31:02Z | |
dc.date.issued | 2019-03-01 | |
dc.identifier.issn | 1047-3211 | |
dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/287608 | |
dc.description.abstract | Seminal human brain histology work has demonstrated developmental waves of myelination. Here, using a micro-structural magnetic resonance imaging (MRI) marker linked to myelin, we studied fine-grained age differences to deduce waves of growth, stability, and decline of cortical myelination over the life-cycle. In 484 participants, aged 8-85 years, we fitted smooth growth curves to T1- to T2-weighted ratio in each of 360 regions from one of seven cytoarchitectonic classes. From the first derivatives of these generally inverted-U trajectories, we defined three milestones: the age at peak growth; the age at onset of a stable plateau; and the age at the onset of decline. Age at peak growth had a bimodal distribution comprising an early (pre-pubertal) wave of primary sensory and motor cortices and a later (post-pubertal) wave of association, insular and limbic cortices. Most regions reached stability in the 30-s but there was a second wave reaching stability in the 50-s. Age at onset of decline was also bimodal: in some right hemisphere regions, the curve declined from the 60-s, but in other left hemisphere regions, there was no significant decline from the stable plateau. These results are consistent with regionally heterogeneous waves of intracortical myelinogenesis and age-related demyelination. | |
dc.description.sponsorship | This work was supported by the Department of Psychology, University of Oslo (to K.B.W., A.M.F.); the Norwegian Research Council (to K.B.W., A.M.F.); and the European Research Council’s Starting/Consolidator Grant schemes (grant agreements 283634, 725025 (to A.M.F.) and 313440 (to K.B.W.)). P.E.V. was supported by the Medical Research Council (grant number MR/K020706/1) and is a Fellow of MQ: Transforming Mental Health (grant number MQF17_24). F.V. was supported by the Gates Cambridge Trust. K.W. is supported by a research fellowship at the Alan Turing Institute under the EPSRC (grant EP/N510129/1). S.R.W. was supported by the Medical Research Council, UK (Unit Programme number U105292687). This work was supported by the NIHR Cambridge Biomedical Research Centre. | |
dc.format.medium | ||
dc.language | eng | |
dc.publisher | Oxford University Press (OUP) | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Cerebral Cortex | |
dc.subject | Myelin Sheath | |
dc.subject | Humans | |
dc.subject | Magnetic Resonance Imaging | |
dc.subject | Longevity | |
dc.subject | Adolescent | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Middle Aged | |
dc.subject | Child | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Young Adult | |
dc.subject | Connectome | |
dc.title | Waves of Maturation and Senescence in Micro-structural MRI Markers of Human Cortical Myelination over the Lifespan. | |
dc.type | Article | |
prism.endingPage | 1381 | |
prism.issueIdentifier | 3 | |
prism.publicationDate | 2019 | |
prism.publicationName | Cereb Cortex | |
prism.startingPage | 1369 | |
prism.volume | 29 | |
dc.identifier.doi | 10.17863/CAM.34920 | |
dcterms.dateAccepted | 2018-11-30 | |
rioxxterms.versionofrecord | 10.1093/cercor/bhy330 | |
rioxxterms.version | VoR | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2019-03 | |
dc.contributor.orcid | Vertes, Petra [0000-0002-0992-3210] | |
dc.contributor.orcid | Whitaker, Kirstie [0000-0001-8498-4059] | |
dc.contributor.orcid | White, Simon [0000-0001-8642-7037] | |
dc.contributor.orcid | Bullmore, Edward [0000-0002-8955-8283] | |
dc.identifier.eissn | 1460-2199 | |
rioxxterms.type | Journal Article/Review | |
pubs.funder-project-id | Cambridge University Hospitals NHS Foundation Trust (CUH) (unknown) | |
pubs.funder-project-id | MRC (1185) | |
pubs.funder-project-id | MQ: Transforming Mental Health (MQ17-24 Vertes) | |
pubs.funder-project-id | Medical Research Council (MR/K020706/1) | |
pubs.funder-project-id | MRC (unknown) | |
cam.issuedOnline | 2018-12-27 |
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