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dc.contributor.authorKhan, Wasimen
dc.date.accessioned2019-02-13T00:31:07Z
dc.date.available2019-02-13T00:31:07Z
dc.identifier.issn2077-0383
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/289334
dc.description.abstractPeriprosthetic joint infection in total knee arthroplasty is a significant complication that is a common reason for revision surgery. The current standard of care is two-stage revision surgery. There is however increasing evidence to support the use of single-stage revision surgery. We conducted a PRISMA systematic review of the current evidence on the use of single-stage revision for infected total knee arthroplasty. Four databases (PubMed, Embase, Science Direct, and Cochrane Library) were systematically screened for eligible studies. The risk bias of each study was identified using ROBINS-I tool, and the quality of evidence was assessed using the GRADE criteria. Sixteen articles were retained after applying the inclusion and exclusion criteria that evaluated 3,645 knee single-stage revision surgeries. Our review reveals satisfactory outcomes for single-stage revision in the management of infected total knee arthroplasty. The reinfection rates in the studies included in our review varied however the majority reported low reinfection rates and good functional outcomes. Although strict patient selection criteria have yielded successful results, good results were also reported when these criteria were not applied. The greater use of risk factors in identifying patients likely to have a successful outcome needs to be balanced with the practical benefits of performing a single stage procedure in higher risk patients. Future large clinical randomized control trials are required to confirm our results.
dc.publisherMDPI AG
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleSingle-Stage Revision Surgery in Infected Total Knee Arthroplasty: A PRISMA Systematic Reviewen
dc.typeArticle
prism.publicationNameJournal of Clinical Medicineen
dc.identifier.doi10.17863/CAM.36583
dcterms.dateAccepted2019-01-29en
rioxxterms.versionofrecord10.3390/jcm8020174en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2019-01-29en
dc.contributor.orcidKhan, Wasim [0000-0003-3106-5424]
dc.identifier.eissn2077-0383
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2019-02-02en


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International