Show simple item record

dc.contributor.authorSun, Zoe Dong Yangen
dc.contributor.authorCheriyan, Josephen
dc.date.accessioned2019-02-16T00:30:31Z
dc.date.available2019-02-16T00:30:31Z
dc.date.issued2019-08en
dc.identifier.issn1355-6037
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/289484
dc.description.abstractCardiovascular (CV) disease remains the leading cause of deaths worldwide, accounting for 32% of global deaths (1). CV mortality reduction is a key focus of the United Nations Healthy Strategy (2) but in order to achieve this, there is a need to improve risk stratification (3, 4). Nearly half of all CV deaths are attributable to coronary artery disease (CAD) (1). Current risk stratification for suspected CAD uses a pre-test probability (PTP) based on the nature of chest pain, gender and age to decide on the subsequent intervention. In those with low PTP for CAD, the Framingham Risk Score (FRS) (5) discriminates the risk of CV events well for subsequent primary prevention (6). Individuals with a high PTP can reach a diagnosis of CAD and proceed to optimal medical therapy or invasive coronary angiography depending on symptom severity (5). There is a large group of individuals with intermediate PTP who proceed to further investigations with coronary imaging or stress testing (5), however a positive stress test only identifies less than half (7, 8) whilst coronary imaging defines less than a third of those who develop a subsequently develop a CV event (5, 7). Therefore, risk stratification with additional assessments may be beneficial. Measures of arterial stiffness and endothelial function provide global measures of arterial health. In this review, we focus on arterial stiffness measured by pulse wave velocity (PWV), arterial wave reflections by augmentation index (AIx) and endothelial function measured by either flow-mediated dilatation (FMD), forearm blood flow or digital reactive hyperaemia.
dc.description.sponsorshipNone
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherBMJ Publishing Group
dc.subjectHumansen
dc.subjectVascular Diseasesen
dc.subjectDiagnostic Techniques, Cardiovascularen
dc.subjectRisk Factorsen
dc.subjectPatient Selectionen
dc.titleNon-invasive measurements of arterial function: What? When? Why should we use them?en
dc.typeArticle
prism.endingPage1211
prism.issueIdentifier15en
prism.publicationDate2019en
prism.publicationNameHeart (British Cardiac Society)en
prism.startingPage1203
prism.volume105en
dc.identifier.doi10.17863/CAM.36734
dcterms.dateAccepted2019-01-27en
rioxxterms.versionofrecord10.1136/heartjnl-2018-312970en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-08en
dc.contributor.orcidCheriyan, Joseph [0000-0001-6921-1592]
dc.identifier.eissn1468-201X
rioxxterms.typeJournal Article/Reviewen
cam.orpheus.successThu Jan 30 10:51:00 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2019-08-31


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record