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dc.contributor.authorWhitworth, Alexen
dc.contributor.authorPallanck, Leo Jen
dc.date.accessioned2019-04-03T13:19:39Z
dc.date.available2019-04-03T13:19:39Z
dc.date.issued2017-06en
dc.identifier.issn0959-437X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/291061
dc.description.abstractMitochondria are essential organelles that provide cellular energy and buffer cytoplasmic calcium. At the same time they produce damaging reactive oxygen species and sequester pro-apoptotic factors. Hence, eukaryotes have evolved exquisite homeostatic processes that maintain mitochondrial integrity, or ultimately remove damaged organelles. This subject has garnered intense interest recently following the discovery that two Parkinson's disease genes, PINK1 and parkin, regulate mitochondrial degradation (mitophagy). The molecular details of PINK1/Parkin-induced mitophagy are emerging but much of our insight derives from work using cultured cells and potent mitochondrial toxins, raising questions about the physiological significance of these findings. Here we review the evidence supporting PINK1/Parkin mitophagy in vivo and its causative role in neurodegeneration, and outline outstanding questions for future investigations.
dc.description.sponsorshipAJW acknowledges funding from the MRC (MC-A070-5PSB0) and ERC (StG 309742), and LJP acknowledges funding from the NIH (5R01GM104990).
dc.languageengen
dc.publisherElsevier BV
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCalciumen
dc.subjectHumansen
dc.subjectMitochondriaen
dc.subjectMitochondrial Degradationen
dc.subjectNerve Degenerationen
dc.subjectParkinson Diseaseen
dc.subjectProtein Kinasesen
dc.subjectReactive Oxygen Speciesen
dc.subjectUbiquitin-Protein Ligasesen
dc.titlePINK1/Parkin mitophagy and neurodegeneration-what do we really know in vivo?en
dc.typeArticle
prism.endingPage53
prism.publicationDate2017en
prism.publicationNameCurrent Opinion in Genetics & Developmenten
prism.startingPage47
prism.volume44en
dc.identifier.doi10.17863/CAM.38242
dcterms.dateAccepted2017-01-26en
rioxxterms.versionofrecord10.1016/j.gde.2017.01.016en
rioxxterms.versionVoR*
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2017-06en
dc.contributor.orcidWhitworth, Alex [0000-0002-1154-6629]
dc.identifier.eissn1879-0380
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_00015/6)
pubs.funder-project-idMRC (MC_UP_1501/1)
cam.issuedOnline2017-02-16en
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0959437X16302155?via%3Dihuben


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International