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dc.contributor.authorAvgoulas, Evangelos Ien
dc.contributor.authorSutcliffe, Michaelen
dc.contributor.authorLinderman, Stephen Wen
dc.contributor.authorBirman, Victoren
dc.contributor.authorThomopoulos, Stavrosen
dc.contributor.authorGenin, Guy Men
dc.date.accessioned2019-04-03T23:30:27Z
dc.date.available2019-04-03T23:30:27Z
dc.date.issued2019-04en
dc.identifier.issn1742-5689
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/291083
dc.description.abstractSurgical reattachment of tendon to bone is a procedure marked by high failure rates. For example, nearly all rotator cuff repairs performed on elderly patients with massive tears ultimately result in recurrence of tearing. These high failure rates have been attributed to stress concentrations that arise due to the mechanical mismatch between tendon and bone. Although recent studies have identified potential adhesives with mechanical properties tuned to alleviate these stress concentrations and thereby delay the onset of failure, resistance to the progression of failure has not been studied. Here, we refined the space of adhesive material properties that can improve surgical attachment by considering the fracture process. Using cohesive zone modeling and physiologically relevant values of mode I and mode II adhesive fracture toughnesses, we predicted the maximum displacement and strength at failure of idealized, adhesively bonded tendon-to-bone repairs. Repair failure occurred due to excessive relative displacement of the tendon and bone tissues for strong and compliant adhesives. The failure mechanism shifted to rupture of the entire repair for stiffer adhesives below a critical shear strength. Results identified a narrow range of materials on an Ashby chart that are suitable for adhesive repair of tendon to bone, including a range of elastomers and porous solids.
dc.description.sponsorshipEPSRC
dc.format.mediumPrinten
dc.languageengen
dc.publisherThe Royal Society
dc.rightsAll rights reserved
dc.subjectBone and Bonesen
dc.subjectTendonsen
dc.subjectAnimalsen
dc.subjectHumansen
dc.subjectTendon Injuriesen
dc.subjectBiocompatible Materialsen
dc.subjectAdhesivesen
dc.subjectWound Healingen
dc.subjectStress, Mechanicalen
dc.subjectModels, Biologicalen
dc.subjectBiomechanical Phenomenaen
dc.titleAdhesive-based tendon-to-bone repair: failure modelling and materials selection.en
dc.typeArticle
prism.issueIdentifier153en
prism.publicationDate2019en
prism.publicationNameJournal of the Royal Society, Interfaceen
prism.startingPage20180838
prism.volume16en
dc.identifier.doi10.17863/CAM.38264
dcterms.dateAccepted2019-03-11en
rioxxterms.versionofrecord10.1098/rsif.2018.0838en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-04en
dc.contributor.orcidSutcliffe, Michael [0000-0001-9729-4460]
dc.identifier.eissn1742-5662
rioxxterms.typeJournal Article/Reviewen
cam.orpheus.successThu Jan 30 10:49:07 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2019-04-30


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