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dc.contributor.authorPartap, Uttaraen
dc.contributor.authorAllcock, Sophie Hen
dc.contributor.authorParker, Edythen
dc.contributor.authorGurdasani, Deeptien
dc.contributor.authorYoung, Elizabeth Hen
dc.contributor.authorSandhu, Manjinderen
dc.date.accessioned2019-04-10T23:31:32Z
dc.date.available2019-04-10T23:31:32Z
dc.identifier.issn2054-4200
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/291463
dc.description.abstractBackground: Recent research implicates antibiotic use as a potential contributor to child obesity risk. In this narrative review, we examine current observational evidence on the relation between antibiotic use in early childhood and subsequent measures of child body mass. Methods: We searched PubMed, Web of Science and the Cochrane Library to identify studies that assessed antibiotic exposure before 3 years of age and subsequent measures of body mass or risk of overweight or obesity in childhood. Results: We identified 13 studies published before October 2017, based on a total of 6 81 332 individuals, which examined the relation between early life antibiotic exposure and measures of child body mass. Most studies did not appropriately account for confounding by indication for antibiotic use. Overall, we found no consistent and conclusive evidence of associations between early life antibiotic use and later child body mass [minimum overall adjusted odds ratio (aOR) reported: 1.01, 95% confidence interval (95% CI) 0.98-1.04, N = 2 60 556; maximum overall aOR reported: 2.56, 95% CI 1.36-4.79, N = 616], with no clinically meaningful increases in weight reported (maximum increase: 1.50 kg at 15 years of age). Notable methodological differences between studies, including variable measures of association and inclusion of confounders, limited more comprehensive interpretations. Conclusions: Evidence to date is insufficient to indicate that antibiotic use is an important risk factor for child obesity, or leads to clinically important differences in weight. Further comparable studies using routine clinical data may help clarify this association.
dc.description.sponsorshipThis work was supported by the Wellcome Trust (grant number 206194), the African Partnership for Chronic Disease Research (Medical Research Council UK partnership grant number MR/K013491/1) and the National Institute for Health Research Cambridge Biomedical Research Centre (UK). EP is supported by the Gates Cambridge Trust.
dc.languageengen
dc.publisherCambridge University Press
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAntibioticsen
dc.subjectchild obesityen
dc.subjectchild overweighten
dc.subjectearly lifeen
dc.titleAssociation between early life antibiotic use and childhood overweight and obesity: a narrative review.en
dc.typeArticle
prism.numbere18en
prism.publicationNameGlobal Health, Epidemiology and Genomicsen
prism.volume3en
dc.identifier.doi10.17863/CAM.38631
dcterms.dateAccepted2018-09-16en
rioxxterms.versionofrecord10.1017/gheg.2018.16en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-09-16en
dc.contributor.orcidSandhu, Manjinder [0000-0002-2725-142X]
dc.identifier.eissn2054-4200
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MR/K013491/1)
pubs.funder-project-idWellcome Trust Sanger Institute, Genome Research Limited (S0817)
cam.issuedOnline2018-10-24en


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International