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dc.contributor.authorCooper, Lauraen
dc.contributor.authorRobson, Annaen
dc.contributor.authorTrotter, Carolineen
dc.contributor.authorAseffa, Abrahamen
dc.contributor.authorCollard, Jean-Marcen
dc.contributor.authorDaugla, Doumagoum Motoen
dc.contributor.authorDiallo, Aldioumaen
dc.contributor.authorHodgson, Abrahamen
dc.contributor.authorJusot, Jean-Françoisen
dc.contributor.authorOmotara, Babatunjien
dc.contributor.authorSow, Sambaen
dc.contributor.authorHassan-King, Musaen
dc.contributor.authorManigart, Olivieren
dc.contributor.authorNascimento, Mariaen
dc.contributor.authorWoukeu, Arounaen
dc.contributor.authorChandramohan, Danielen
dc.contributor.authorBorrow, Rayen
dc.contributor.authorMaiden, Martin CJen
dc.contributor.authorGreenwood, Brianen
dc.contributor.authorStuart, James Men
dc.contributor.authorMenAfriCar Consortium,en
dc.date.accessioned2019-05-01T11:49:12Z
dc.date.available2019-05-01T11:49:12Z
dc.date.issued2019-04en
dc.identifier.issn1360-2276
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/292154
dc.description.abstractOBJECTIVE: To investigate potential risk factors for acquisition in seven countries of the meningitis belt. METHODS: Households were followed up every 2 weeks for 2 months, then monthly for a further 4 months. Pharyngeal swabs were collected from all available household members at each visit and questionnaires completed. Risks of acquisition over the whole study period and for each visit were analysed by a series of logistic regressions. RESULTS: Over the course of the study, acquisition was higher in: (i) 5-to 14-year olds, as compared with those 30 years or older (OR 3.6, 95% CI 1.4-9.9); (ii) smokers (OR 3.6, 95% CI 0.98-13); and (iii) those exposed to wood smoke at home (OR 2.6 95% CI 1.3-5.6). The risk of acquisition from one visit to the next was higher in those reporting a sore throat during the dry season (OR 3.7, 95% CI 2.0-6.7) and lower in those reporting antibiotic use (OR 0.17, 95% CI 0.03-0.56). CONCLUSIONS: Acquisition of meningococcal carriage peaked in school age children. Recent symptoms of sore throat during the dry season, but not during the rainy season, were associated with a higher risk of acquisition. Upper respiratory tract infections may be an important driver of epidemics in the meningitis belt.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.language.isoenen
dc.subjectMenAfriCar Consortiumen
dc.subjectHumansen
dc.subjectNeisseria meningitidis, Serogroup Aen
dc.subjectMeningitis, Meningococcalen
dc.subjectRespiratory Tract Infectionsen
dc.subjectPharyngitisen
dc.subjectAnti-Bacterial Agentsen
dc.subjectLogistic Modelsen
dc.subjectRisk Factorsen
dc.subjectCross-Sectional Studiesen
dc.subjectSmokingen
dc.subjectSeasonsen
dc.subjectCarrier Stateen
dc.subjectSmokeen
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectMiddle Ageden
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectInfanten
dc.subjectAfrica South of the Saharaen
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectYoung Adulten
dc.titleRisk factors for acquisition of meningococcal carriage in the African meningitis belt.en
dc.typeArticle
prism.endingPage400
prism.issueIdentifier4en
prism.publicationDate2019en
prism.publicationNameTropical medicine & international health : TM & IHen
prism.startingPage392
prism.volume24en
dc.identifier.doi10.17863/CAM.39306
dcterms.dateAccepted2019-01-22en
rioxxterms.versionofrecord10.1111/tmi.13203en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-04en
dc.contributor.orcidCooper, Laura [0000-0002-2942-3627]
dc.contributor.orcidTrotter, Caroline [0000-0003-4000-2708]
dc.contributor.orcidAseffa, Abraham [0000-0002-8028-1150]
dc.identifier.eissn1365-3156
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBill & Melinda Gates Foundation (via London School of Hygiene & Tropical Medicine) (ITDCVT64: UCAM)
cam.orpheus.successThu Jan 30 10:45:56 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-04-30


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