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dc.contributor.authorPereira-Leal, Jose B
dc.contributor.authorLevy, Emmanuel D
dc.contributor.authorKamp, Christel
dc.contributor.authorTeichmann, Sarah
dc.date.accessioned2019-05-16T23:30:48Z
dc.date.available2019-05-16T23:30:48Z
dc.date.issued2007
dc.identifier.issn1474-7596
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/292896
dc.description.abstractBACKGROUND: Cellular functions are accomplished by the concerted actions of functional modules. The mechanisms driving the emergence and evolution of these modules are still unclear. Here we investigate the evolutionary origins of protein complexes, modules in physical protein-protein interaction networks. RESULTS: We studied protein complexes in Saccharomyces cerevisiae, complexes of known three-dimensional structure in the Protein Data Bank and clusters of pairwise protein interactions in the networks of several organisms. We found that duplication of homomeric interactions, a large class of protein interactions, frequently results in the formation of complexes of paralogous proteins. This route is a common mechanism for the evolution of complexes and clusters of protein interactions. Our conclusions are further confirmed by theoretical modelling of network evolution. We propose reasons for why this is favourable in terms of structure and function of protein complexes. CONCLUSION: Our study provides the first insight into the evolution of functional modularity in protein-protein interaction networks, and the origins of a large class of protein complexes.
dc.format.mediumPrint
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectSaccharomyces cerevisiae
dc.subjectMultiprotein Complexes
dc.subjectSaccharomyces cerevisiae Proteins
dc.subjectProtein Subunits
dc.subjectEvolution, Molecular
dc.subjectGene Duplication
dc.subjectProtein Structure, Quaternary
dc.subjectDimerization
dc.subjectModels, Genetic
dc.subjectModels, Molecular
dc.titleEvolution of protein complexes by duplication of homomeric interactions.
dc.typeArticle
prism.issueIdentifier4
prism.publicationDate2007
prism.publicationNameGenome Biol
prism.startingPageR51
prism.volume8
dc.identifier.doi10.17863/CAM.40048
dcterms.dateAccepted2007-04-05
rioxxterms.versionofrecord10.1186/gb-2007-8-4-r51
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2007-01
dc.contributor.orcidTeichmann, Sarah [0000-0002-6294-6366]
dc.identifier.eissn1474-760X
rioxxterms.typeJournal Article/Review


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International