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dc.contributor.authorMajander, A
dc.contributor.authorRobson, AG
dc.contributor.authorJoão, C
dc.contributor.authorHolder, GE
dc.contributor.authorChinnery, Patrick
dc.contributor.authorMoore, AT
dc.contributor.authorVotruba, M
dc.contributor.authorStockman, A
dc.contributor.authorYu Wai Man, Patrick
dc.date.accessioned2019-07-26T23:30:24Z
dc.date.available2019-07-26T23:30:24Z
dc.date.issued2017-09
dc.identifier.issn1567-7249
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/294993
dc.description.abstractLeber inherited optic neuropathy (LHON) is characterized by subacute bilateral loss of central vision due to dysfunction and loss of retinal ganglion cells (RGCs). Comprehensive visual electrophysiological investigations (including pattern reversal visual evoked potentials, pattern electroretinography and the photopic negative response) performed on 13 patients with acute and chronic LHON indicate early impairment of RGC cell body function and severe axonal dysfunction. Temporal, spatial and chromatic psychophysical tests performed on 7 patients with acute LHON and 4 patients with chronic LHON suggest severe involvement or loss of the midget, parasol and bistratified RGCs associated with all three principal visual pathways.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherElsevier BV
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectVisual Pathways
dc.subjectRetinal Ganglion Cells
dc.subjectHumans
dc.subjectOptic Atrophy, Hereditary, Leber
dc.subjectProspective Studies
dc.subjectAdolescent
dc.subjectAdult
dc.subjectMiddle Aged
dc.subjectChild
dc.subjectFemale
dc.subjectMale
dc.subjectYoung Adult
dc.titleThe pattern of retinal ganglion cell dysfunction in Leber hereditary optic neuropathy.
dc.typeArticle
prism.endingPage149
prism.publicationDate2017
prism.publicationNameMitochondrion
prism.startingPage138
prism.volume36
dc.identifier.doi10.17863/CAM.42074
dcterms.dateAccepted2017-07-14
rioxxterms.versionofrecord10.1016/j.mito.2017.07.006
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-09
dc.contributor.orcidChinnery, Patrick [0000-0002-7065-6617]
dc.contributor.orcidYu Wai Man, Patrick [0000-0001-7847-9320]
dc.identifier.eissn1872-8278
rioxxterms.typeJournal Article/Review


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International