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dc.contributor.authorHeath, Christopher Jen
dc.contributor.authorO'Callaghan, Claireen
dc.contributor.authorMason, Sarahen
dc.contributor.authorPhillips, Benjamin Uen
dc.contributor.authorSaksida, Lisaen
dc.contributor.authorRobbins, Trevoren
dc.contributor.authorBarker, Rogeren
dc.contributor.authorBussey, Timothyen
dc.contributor.authorSahakian, Barbaraen
dc.date.accessioned2019-07-30T23:30:13Z
dc.date.available2019-07-30T23:30:13Z
dc.date.issued2019-01en
dc.identifier.issn1664-2295
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/295088
dc.description.abstractApathy is pervasive across many neuropsychiatric disorders but is poorly characterised mechanistically, so targeted therapeutic interventions remain elusive. A key impediment has been the lack of validated assessment tools to facilitate translation of promising findings between preclinical disease models and patients. Apathy is a common symptom in Huntington’s disease. Due to its established genetic basis and the availability of defined animal models, this disease offers a robust translational framework for linking motivated behaviour with underlying neurobiology and an ideal context in which to evaluate a quantitative, translational apathy assessment method. In this study we therefore aimed to demonstrate the validity of using touchscreen-delivered progressive ratio tasks to mirror apathy assessment in Huntington’s disease patients and a representative mouse model. To do this we evaluated Huntington’s disease patients (n=23) and age-matched healthy controls (n=20), and male R6/1 mice (n=23) and wildtype controls (n=29) for apathy-like behaviour using touchscreen-delivered progressive ratio tasks. The primary outcome measure of the assessment was breakpoint, defined as the highest number of touchscreen responses emitted before task engagement ceased. Patients and R6/1 mice were both found to exhibit significantly reduced breakpoints relative to their respective control groups, consistent with apathy-like behaviour. This performance was also not associated with motoric differences in either species. These data demonstrate the utility of touchscreen-delivered progressive ratio tasks in detecting clinically relevant motivational deficits in Huntington’s disease. This approach may offer a platform from which clinically relevant mechanistic insights concerning motivation symptoms can be derived and provide an effective route for translation of promising preclinical findings into viable therapeutic interventions.
dc.description.sponsorshipWellcome Trust
dc.format.mediumElectronic-eCollectionen
dc.languageengen
dc.publisherFrontiers Media
dc.rightsAll rights reserved
dc.titleA Touchscreen Motivation Assessment Evaluated in Huntington's Disease Patients and R6/1 Model Mice.en
dc.typeArticle
prism.publicationDate2019en
prism.publicationNameFrontiers in neurologyen
prism.startingPage858
prism.volume10en
dc.identifier.doi10.17863/CAM.42164
dcterms.dateAccepted2019-07-24en
rioxxterms.versionofrecord10.3389/fneur.2019.00858en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-01en
dc.contributor.orcidO'Callaghan, Claire [0000-0001-5698-6364]
dc.contributor.orcidMason, Sarah [0000-0001-6715-4109]
dc.contributor.orcidRobbins, Trevor [0000-0003-0642-5977]
dc.contributor.orcidBarker, Roger [0000-0001-8843-7730]
dc.contributor.orcidSahakian, Barbara [0000-0001-7352-1745]
dc.identifier.eissn1664-2295
rioxxterms.typeJournal Article/Reviewen
rioxxterms.freetoread.startdate2022-07-30


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