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dc.contributor.authorLee, Chuen Wai
dc.date.accessioned2019-08-08T14:43:55Z
dc.date.available2019-08-08T14:43:55Z
dc.date.issued2019-10-26
dc.date.submitted2018-11-07
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/295486
dc.description.abstractDeveloping techniques to monitor cerebral function is becoming increasingly recognised as a way forward to detect and understand brain injury in patients. Diffuse optical tomography (DOT) is a promising imaging technique that is non-invasive, portable and relatively simple to operate. In this thesis, I describe the development and design of DOT headgear for neonates and subsequently apply this in neonatal studies of cerebral function. Firstly, the DOT headgear was applied to healthy neonates to investigate the early stages of vocal specialisation. In this functional activation study, the cerebral haemodynamic changes observed in response to vocal and non-vocal stimuli are presented in Chapter 6. In recent years, the study of spontaneous cerebral activity that gives rise to resting state networks (RSNs) is becoming widely popular. These studies rely on infants to remain asleep to minimise subject motion and optimise data quality. Using DOT combined with electroencephalography (EEG), the effect of sleep state on RSNs was studied for the first time in healthy neonates with compelling results that are presented in Chapter 7. In the context of sleep state and RSNs, combined DOT-EEG was also applied to neurologically compromised patients in the neonatal intensive care unit (NICU). The results of this case-based study are presented in Chapter 8. These studies demonstrate the potential clinical use of DOT in neonates to evaluate cerebral function. In completion of this thesis, the implications of the results and findings from the studies are discussed and future directions explored.
dc.description.sponsorshipFunding from MRC Clinical Research Training Fellowship (MR/L017490/1, Sept 2014 – Oct 2016) and Evelyn Trust Research Training Fellowship in Perinatal Neuroscience (09/26 2013 RTF, Sept 2013 – Aug 2014).
dc.language.isoen
dc.rightsAll rights reserved
dc.rightsAll Rights Reserveden
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved/en
dc.subjectneonate
dc.subjectnewborn
dc.subjectoptics
dc.subjectnear-infrared spectroscopy
dc.subjectfunctional imaging
dc.subjectresting state networks
dc.subjectsleep state
dc.subjectbrain injury
dc.subjectoptical tomography
dc.titleInvestigating Cerebral Function in Neonates Using Diffuse Optical Tomography
dc.typeThesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (PhD)
dc.publisher.institutionUniversity of Cambridge
dc.publisher.departmentDepartment of Obstetrics and Gynaecology
dc.date.updated2019-08-08T13:41:27Z
dc.identifier.doi10.17863/CAM.42541
dc.contributor.orcidLee, Chuen Wai [0000-0001-7785-2963]
dc.publisher.collegeTrinity Hall
dc.type.qualificationtitlePhD in Obstetrics and Gynaecology
cam.supervisorAustin, Topun
cam.supervisorCooper, Rob
cam.supervisor.orcidAustin, Topun [0000-0002-8428-8624]
cam.thesis.fundingtrue
rioxxterms.freetoread.startdate2021-08-08


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