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dc.contributor.authorKapetas, Panagiotisen
dc.contributor.authorClauser, Paolaen
dc.contributor.authorWoitek, Ramonaen
dc.contributor.authorWengert, Georg Jen
dc.contributor.authorLazar, Mathiasen
dc.contributor.authorPinker, Katjaen
dc.contributor.authorHelbich, Thomas Hen
dc.contributor.authorBaltzer, Pascal ATen
dc.date.accessioned2019-09-10T23:31:26Z
dc.date.available2019-09-10T23:31:26Z
dc.date.issued2019-05en
dc.identifier.issn0020-9996
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/296750
dc.description.abstractOBJECTIVES: The aim of this study was to evaluate breast multiparametric ultrasound (mpUS) and its potential to reduce unnecessary breast biopsies with 1, 2, or 3 additional quantitative parameters (Doppler, elastography, and contrast-enhanced ultrasound [CEUS]) to B-mode and investigate possible variations with different reader experience. MATERIALS AND METHODS: This prospective study included 124 women (age range, 18-82 years; mean, 52 years), each with 1 new breast lesion, scheduled for ultrasound-guided biopsy between October 2015 and September 2016. Each lesion was examined with B-mode, elastography (Virtual Touch IQ [VTIQ]), Doppler, and CEUS, and different quantitative parameters were recorded for each modality. Four readers (2 experienced breast radiologists and 2 in-training) independently evaluated B-mode images of each lesion and assigned a BI-RADS (Breast Imaging Reporting and Data System) score. Using the area under the receiver operating characteristic curve (AUC), the most accurate quantitative parameter for each modality was chosen. These were then combined with the BI-RADS scores of all readers. Descriptive statistics and AUC were used to evaluate the diagnostic performance of mpUS. RESULTS: Sixty-five lesions were malignant. MpUS with B-mode and 2 additional quantitative parameters (VTIQ and CEUS or Doppler) showed the highest diagnostic performance for all readers (averaged AUCs, 0.812-0.789 respectively vs 0.683 for B-mode, P = 0.0001). Both combinations significantly reduced the number of false-positive findings up to 46.9% (P < 0.0001). CONCLUSIONS: Quantitative mpUS with 2 different triple assessment modalities (B-mode, VTIQ elastography, CEUS, or Doppler) shows the best diagnostic performance for breast cancer diagnosis and leads to a significant reduction of false-positive biopsy recommendations, for both experienced and inexperienced readers.
dc.languageengen
dc.publisherWolters Kluwer Health
dc.rightsAll rights reserved
dc.rights.uri
dc.titleQuantitative Multiparametric Breast Ultrasound: Application of Contrast-Enhanced Ultrasound and Elastography Leads to an Improved Differentiation of Benign and Malignant Lesions.en
dc.typeArticle
prism.endingPage264
prism.issueIdentifier5en
prism.publicationDate2019en
prism.publicationNameInvestigative Radiologyen
prism.startingPage257
prism.volume54en
dc.identifier.doi10.17863/CAM.43793
dcterms.dateAccepted2018-11-16en
rioxxterms.versionofrecord10.1097/RLI.0000000000000543en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-05en
dc.contributor.orcidWoitek, Ramona [0000-0002-9146-9159]
dc.identifier.eissn1536-0210
rioxxterms.typeJournal Article/Reviewen
rioxxterms.freetoread.startdate2020-05-31


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