Show simple item record

dc.contributor.authorFlodén, Nilsen
dc.contributor.authorTrowbridge, Aaronen
dc.contributor.authorGaunt, Matthewen
dc.contributor.authorWillcox, Darrenen
dc.contributor.authorWalton, Scarletten
dc.contributor.authorKim, Yongjoonen
dc.date.accessioned2019-09-17T23:30:12Z
dc.date.available2019-09-17T23:30:12Z
dc.identifier.issn0002-7863
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/296890
dc.description.abstractWe report a general visible-light-mediated strategy that enables the construction of complex C(sp3)-rich N-heterospirocycles from feedstock aliphatic ketones and aldehydes with a broad selection of alkene-containing secondary amines. Key to the success of this approach was the utilization of a highly reducing Ir-photocatalyst and orchestration of the intrinsic reactivities of 1,4-cyclohexadiene and Hantzsch ester. This methodology provides streamlined access to complex C(sp3)-rich N-heterospirocycles displaying structural and functional features relevant to fragment-based lead identification programs.
dc.description.sponsorshipWe are grateful to the Gates Cambridge Trust (N.J.F.) and Herchel Smith Scholarship Scheme (A.T.) for studentships, the EPSRC (EP/S020292/1 and EP/N031792/1), Ambitious Leader’s Program, Hokkaido University, Japan (Y.K.), and the Royal Society for a Wolfson Merit Award (M.J.G.). S.M.W. is a Fellow of the AstraZeneca Postdoctoral program. We are grateful to the EPSRC UK National Mass Spectrometry Facility at Swansea University for HRMS analysis.
dc.publisherAmerican Chemical Society
dc.rightsAll rights reserved
dc.rights.uri
dc.titleStreamlined Synthesis of C(sp3)-Rich N-Heterospirocycles Enabled by Visible-Light-Mediated Photocatalysisen
dc.typeArticle
prism.endingPage8430
prism.publicationNameJournal of the American Chemical Societyen
prism.startingPage8426
prism.volume141en
dc.identifier.doi10.17863/CAM.43931
dcterms.dateAccepted2019-05-09en
rioxxterms.versionofrecord10.1021/jacs.9b03372en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-05-09en
dc.contributor.orcidGaunt, Matthew [0000-0002-7214-608X]
dc.contributor.orcidWillcox, Darren [0000-0002-1396-7734]
dc.identifier.eissn1520-5126
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEPSRC (EP/N031792/1)
pubs.funder-project-idEPSRC (EP/S020292/1)
cam.issuedOnline2019-05-09en
cam.orpheus.successThu Jan 30 10:38:58 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-05-09


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record