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dc.contributor.authorPatel, Vivek L
dc.contributor.authorBusch, Evan L
dc.contributor.authorFriebel, Tara M
dc.contributor.authorCronin, Angel
dc.contributor.authorLeslie, Goska
dc.contributor.authorMcGuffog, Lesley
dc.contributor.authorAdlard, Julian
dc.contributor.authorAgata, Simona
dc.contributor.authorAgnarsson, Bjarni A
dc.contributor.authorAhmed, Munaza
dc.contributor.authorAittomäki, Kristiina
dc.contributor.authorAlducci, Elisa
dc.contributor.authorAndrulis, Irene L
dc.contributor.authorArason, Adalgeir
dc.contributor.authorArnold, Norbert
dc.contributor.authorArtioli, Grazia
dc.contributor.authorArver, Brita
dc.contributor.authorAuber, Bernd
dc.contributor.authorAzzollini, Jacopo
dc.contributor.authorBalmaña, Judith
dc.contributor.authorBarkardottir, Rosa B
dc.contributor.authorBarnes, Daniel
dc.contributor.authorBarroso, Alicia
dc.contributor.authorBarrowdale, Daniel
dc.contributor.authorBelotti, Muriel
dc.contributor.authorBenitez, Javier
dc.contributor.authorBertelsen, Birgitte
dc.contributor.authorBlok, Marinus J
dc.contributor.authorBodrogi, Istvan
dc.contributor.authorBonadona, Valérie
dc.contributor.authorBonanni, Bernardo
dc.contributor.authorBondavalli, Davide
dc.contributor.authorBoonen, Susanne E
dc.contributor.authorBorde, Julika
dc.contributor.authorBorg, Ake
dc.contributor.authorBradbury, Angela R
dc.contributor.authorBrady, Angela
dc.contributor.authorBrewer, Carole
dc.contributor.authorBrunet, Joan
dc.contributor.authorBuecher, Bruno
dc.contributor.authorBuys, Saundra S
dc.contributor.authorCabezas-Camarero, Santiago
dc.contributor.authorCaldés, Trinidad
dc.contributor.authorCaliebe, Almuth
dc.contributor.authorCaligo, Maria A
dc.contributor.authorCalvello, Mariarosaria
dc.contributor.authorCampbell, Ian G
dc.contributor.authorCarnevali, Ileana
dc.contributor.authorCarrasco, Estela
dc.contributor.authorChan, Tsun L
dc.contributor.authorChu, Annie TW
dc.contributor.authorChung, Wendy K
dc.contributor.authorClaes, Kathleen BM
dc.contributor.authorCollaborators, Gemo Study
dc.contributor.authorCollaborators, Embrace
dc.contributor.authorCook, Jackie
dc.contributor.authorCortesi, Laura
dc.contributor.authorCouch, Fergus J
dc.contributor.authorDaly, Mary B
dc.contributor.authorDamante, Giuseppe
dc.contributor.authorDarder, Esther
dc.contributor.authorDavidson, Rosemarie
dc.contributor.authorde la Hoya, Miguel
dc.contributor.authorPuppa, Lara Della
dc.contributor.authorDennis, Joe
dc.contributor.authorDíez, Orland
dc.contributor.authorDing, Yuan Chun
dc.contributor.authorDitsch, Nina
dc.contributor.authorDomchek, Susan M
dc.contributor.authorDonaldson, Alan
dc.contributor.authorDworniczak, Bernd
dc.contributor.authorEaston, Douglas
dc.contributor.authorEccles, Diana M
dc.contributor.authorEeles, Rosalind A
dc.contributor.authorEhrencrona, Hans
dc.contributor.authorEjlertsen, Bent
dc.contributor.authorEngel, Christoph
dc.contributor.authorEvans, D Gareth
dc.contributor.authorFaivre, Laurence
dc.contributor.authorFaust, Ulrike
dc.contributor.authorFeliubadaló, Lídia
dc.contributor.authorForetova, Lenka
dc.contributor.authorFostira, Florentia
dc.contributor.authorFountzilas, George
dc.contributor.authorFrost, Debra
dc.contributor.authorGarcía-Barberán, Vanesa
dc.contributor.authorGarre, Pilar
dc.contributor.authorGauthier-Villars, Marion
dc.contributor.authorGéczi, Lajos
dc.contributor.authorGehrig, Andrea
dc.contributor.authorGerdes, Anne-Marie
dc.contributor.authorGesta, Paul
dc.contributor.authorGiannini, Giuseppe
dc.contributor.authorGlendon, Gord
dc.contributor.authorGodwin, Andrew K
dc.contributor.authorGoldgar, David E
dc.contributor.authorGreene, Mark H
dc.contributor.authorGutierrez-Barrera, Angelica M
dc.contributor.authorHahnen, Eric
dc.contributor.authorHamann, Ute
dc.contributor.authorHauke, Jan
dc.contributor.authorHerold, Natalie
dc.contributor.authorHogervorst, Frans BL
dc.contributor.authorHonisch, Ellen
dc.contributor.authorHopper, John L
dc.contributor.authorHulick, Peter J
dc.contributor.authorInvestigators, KConFab
dc.contributor.authorInvestigators, Hebon
dc.contributor.authorIzatt, Louise
dc.contributor.authorJager, Agnes
dc.contributor.authorJames, Paul
dc.contributor.authorJanavicius, Ramunas
dc.contributor.authorJensen, Uffe Birk
dc.contributor.authorJensen, Thomas Dyrso
dc.contributor.authorJohannsson, Oskar Th
dc.contributor.authorJohn, Esther M
dc.contributor.authorJoseph, Vijai
dc.contributor.authorKang, Eunyoung
dc.contributor.authorKast, Karin
dc.contributor.authorKiiski, Johanna I
dc.contributor.authorKim, Sung-Won
dc.contributor.authorKim, Zisun
dc.contributor.authorKo, Kwang-Pil
dc.contributor.authorKonstantopoulou, Irene
dc.contributor.authorKramer, Gero
dc.contributor.authorKrogh, Lotte
dc.contributor.authorKruse, Torben A
dc.contributor.authorKwong, Ava
dc.contributor.authorLarsen, Mirjam
dc.contributor.authorLasset, Christine
dc.contributor.authorLautrup, Charlotte
dc.contributor.authorLazaro, Conxi
dc.contributor.authorLee, Jihyoun
dc.contributor.authorLee, Jong Won
dc.contributor.authorLee, Min Hyuk
dc.contributor.authorLemke, Johannes
dc.contributor.authorLesueur, Fabienne
dc.contributor.authorLiljegren, Annelie
dc.contributor.authorLindblom, Annika
dc.contributor.authorLlovet, Patricia
dc.contributor.authorLopez-Fernández, Adria
dc.contributor.authorLopez-Perolio, Irene
dc.contributor.authorLorca, Victor
dc.contributor.authorLoud, Jennifer T
dc.contributor.authorMa, Edmond SK
dc.contributor.authorMai, Phuong L
dc.contributor.authorManoukian, Siranoush
dc.contributor.authorMari, Veronique
dc.contributor.authorMartin, Lynn
dc.contributor.authorMatricardi, Laura
dc.contributor.authorMebirouk, Noura
dc.contributor.authorMedici, Veronica
dc.contributor.authorMeijers-Heijboer, Hanne EJ
dc.contributor.authorMeindl, Alfons
dc.contributor.authorMensenkamp, Arjen R
dc.contributor.authorMiller, Clare
dc.contributor.authorGomes, Denise Molina
dc.contributor.authorMontagna, Marco
dc.contributor.authorMooij, Thea M
dc.contributor.authorMoserle, Lidia
dc.contributor.authorMouret-Fourme, Emmanuelle
dc.contributor.authorMulligan, Anna Marie
dc.contributor.authorNathanson, Katherine L
dc.contributor.authorNavratilova, Marie
dc.contributor.authorNevanlinna, Heli
dc.contributor.authorNiederacher, Dieter
dc.contributor.authorNielsen, Finn C Cilius
dc.contributor.authorNikitina-Zake, Liene
dc.contributor.authorOffit, Kenneth
dc.contributor.authorOlah, Edith
dc.contributor.authorOlopade, Olufunmilayo I
dc.contributor.authorOng, Kai-Ren
dc.contributor.authorOsorio, Ana
dc.contributor.authorOtt, Claus-Eric
dc.contributor.authorPalli, Domenico
dc.contributor.authorPark, Sue K
dc.contributor.authorParsons, Michael T
dc.contributor.authorPedersen, Inge Sokilde
dc.contributor.authorPeissel, Bernard
dc.contributor.authorPeixoto, Ana
dc.contributor.authorPérez-Segura, Pedro
dc.contributor.authorPeterlongo, Paolo
dc.contributor.authorPetersen, Annabeth Høgh
dc.contributor.authorPorteous, Mary E
dc.contributor.authorPujana, Miguel Angel
dc.contributor.authorRadice, Paolo
dc.contributor.authorRamser, Juliane
dc.contributor.authorRantala, Johanna
dc.contributor.authorRashid, Muhammad U
dc.contributor.authorRhiem, Kerstin
dc.contributor.authorRizzolo, Piera
dc.contributor.authorRobson, Mark E
dc.contributor.authorRookus, Matti A
dc.contributor.authorRossing, Caroline M
dc.contributor.authorRuddy, Kathryn J
dc.contributor.authorSantos, Catarina
dc.contributor.authorSaule, Claire
dc.contributor.authorScarpitta, Rosa
dc.contributor.authorSchmutzler, Rita K
dc.contributor.authorSchuster, Hélène
dc.contributor.authorSenter, Leigha
dc.contributor.authorSeynaeve, Caroline M
dc.contributor.authorShah, Payal D
dc.contributor.authorSharma, Priyanka
dc.contributor.authorShin, Vivian Y
dc.contributor.authorSilvestri, Valentina
dc.contributor.authorSimard, Jacques
dc.contributor.authorSinger, Christian F
dc.contributor.authorSkytte, Anne-Bine
dc.contributor.authorSnape, Katie
dc.contributor.authorSolano, Angela R
dc.contributor.authorSoucy, Penny
dc.contributor.authorSouthey, Melissa C
dc.contributor.authorSpurdle, Amanda B
dc.contributor.authorSteele, Linda
dc.contributor.authorSteinemann, Doris
dc.contributor.authorStoppa-Lyonnet, Dominique
dc.contributor.authorStradella, Agostina
dc.contributor.authorSunde, Lone
dc.contributor.authorSutter, Christian
dc.contributor.authorTan, Yen Y
dc.contributor.authorTeixeira, Manuel R
dc.contributor.authorTeo, Soo Hwang
dc.contributor.authorThomassen, Mads
dc.contributor.authorTibiletti, Maria Grazia
dc.contributor.authorTischkowitz, Marc
dc.contributor.authorTognazzo, Silvia
dc.contributor.authorToland, Amanda E
dc.contributor.authorTommasi, Stefania
dc.contributor.authorTorres, Diana
dc.contributor.authorToss, Angela
dc.contributor.authorTrainer, Alison H
dc.contributor.authorTung, Nadine
dc.contributor.authorvan Asperen, Christi J
dc.contributor.authorvan der Baan, Frederieke H
dc.contributor.authorvan der Kolk, Lizet E
dc.contributor.authorvan der Luijt, Rob B
dc.contributor.authorvan Hest, Liselotte P
dc.contributor.authorVaresco, Liliana
dc.contributor.authorVaron-Mateeva, Raymonda
dc.contributor.authorViel, Alessandra
dc.contributor.authorVierstraete, Jeroen
dc.contributor.authorVilla, Roberta
dc.contributor.authorvon Wachenfeldt, Anna
dc.contributor.authorWagner, Philipp
dc.contributor.authorWang-Gohrke, Shan
dc.contributor.authorWappenschmidt, Barbara
dc.contributor.authorWeitzel, Jeffrey N
dc.contributor.authorWieme, Greet
dc.contributor.authorYadav, Siddhartha
dc.contributor.authorYannoukakos, Drakoulis
dc.contributor.authorYoon, Sook-Yee
dc.contributor.authorZanzottera, Cristina
dc.contributor.authorZorn, Kristin K
dc.contributor.authorD'Amico, Anthony V
dc.contributor.authorFreedman, Matthew L
dc.contributor.authorPomerantz, Mark M
dc.contributor.authorChenevix-Trench, Georgia
dc.contributor.authorAntoniou, Antonis
dc.contributor.authorNeuhausen, Susan L
dc.contributor.authorOttini, Laura
dc.contributor.authorNielsen, Henriette Roed
dc.contributor.authorRebbeck, Timothy R
dc.date.accessioned2019-10-01T23:30:33Z
dc.date.available2019-10-01T23:30:33Z
dc.date.issued2020-02-01
dc.identifier.issn0008-5472
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/297334
dc.description.abstractPathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer. We evaluated whether PSVs in BRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8+) prostate cancer using an international sample of 65 BRCA1 and 171 BRCA2 male PSV carriers with prostate cancer, and 3,388 BRCA1 and 2,880 BRCA2 male PSV carriers without prostate cancer. PSVs in the 3' region of BRCA2 (c.7914+) were significantly associated with elevated risk of prostate cancer compared with reference bin c.1001-c.7913 [HR = 1.78; 95% confidence interval (CI), 1.25-2.52; P = 0.001], as well as elevated risk of Gleason 8+ prostate cancer (HR = 3.11; 95% CI, 1.63-5.95; P = 0.001). c.756-c.1000 was also associated with elevated prostate cancer risk (HR = 2.83; 95% CI, 1.71-4.68; P = 0.00004) and elevated risk of Gleason 8+ prostate cancer (HR = 4.95; 95% CI, 2.12-11.54; P = 0.0002). No genotype-phenotype associations were detected for PSVs in BRCA1. These results demonstrate that specific BRCA2 PSVs may be associated with elevated risk of developing aggressive prostate cancer. SIGNIFICANCE: Aggressive prostate cancer risk in BRCA2 mutation carriers may vary according to the specific BRCA2 mutation inherited by the at-risk individual.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherAmerican Association for Cancer Research (AACR)
dc.rightsAll rights reserved
dc.subjectHumans
dc.subjectProstatic Neoplasms
dc.subjectGenetic Predisposition to Disease
dc.subjectBRCA1 Protein
dc.subjectBRCA2 Protein
dc.subjectPrognosis
dc.subjectRisk Factors
dc.subjectGenomics
dc.subjectHeterozygote
dc.subjectMutation
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectMale
dc.subjectYoung Adult
dc.subjectGenetic Association Studies
dc.titleAssociation of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness.
dc.typeArticle
prism.endingPage638
prism.issueIdentifier3
prism.publicationDate2020
prism.publicationNameCancer Res
prism.startingPage624
prism.volume80
dc.identifier.doi10.17863/CAM.44383
dcterms.dateAccepted2019-11-08
rioxxterms.versionofrecord10.1158/0008-5472.CAN-19-1840
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2020-02
dc.contributor.orcidLeslie, Goska [0000-0001-5756-6222]
dc.contributor.orcidAdlard, Julian [0000-0002-1693-0435]
dc.contributor.orcidArnold, Norbert [0000-0003-4523-8808]
dc.contributor.orcidAuber, Bernd [0000-0003-1880-291X]
dc.contributor.orcidAzzollini, Jacopo [0000-0002-9364-9778]
dc.contributor.orcidBarnes, Daniel [0000-0002-3781-7570]
dc.contributor.orcidBrunet, Joan [0000-0003-1945-3512]
dc.contributor.orcidCaligo, Maria A [0000-0003-0589-1829]
dc.contributor.orcidCampbell, Ian G [0000-0002-7773-4155]
dc.contributor.orcidClaes, Kathleen BM [0000-0003-0841-7372]
dc.contributor.orcidDarder, Esther [0000-0002-7764-1397]
dc.contributor.orcidDennis, Joe [0000-0003-4591-1214]
dc.contributor.orcidDworniczak, Bernd [0000-0003-4981-7903]
dc.contributor.orcidEaston, Douglas [0000-0003-2444-3247]
dc.contributor.orcidEeles, Rosalind A [0000-0002-3698-6241]
dc.contributor.orcidEhrencrona, Hans [0000-0002-5589-3622]
dc.contributor.orcidEjlertsen, Bent [0000-0001-8761-714X]
dc.contributor.orcidEvans, D Gareth [0000-0002-8482-5784]
dc.contributor.orcidGarre, Pilar [0000-0001-8285-4138]
dc.contributor.orcidGreene, Mark H [0000-0003-1852-9239]
dc.contributor.orcidHulick, Peter J [0000-0001-8397-4078]
dc.contributor.orcidJager, Agnes [0000-0002-7713-1450]
dc.contributor.orcidJames, Paul [0000-0002-4361-4657]
dc.contributor.orcidJohn, Esther M [0000-0003-3259-8003]
dc.contributor.orcidJoseph, Vijai [0000-0002-7933-151X]
dc.contributor.orcidKim, Sung-Won [0000-0002-1413-2800]
dc.contributor.orcidKim, Zisun [0000-0002-1413-2800]
dc.contributor.orcidKonstantopoulou, Irene [0000-0002-0470-0309]
dc.contributor.orcidLesueur, Fabienne [0000-0001-7404-4549]
dc.contributor.orcidMatricardi, Laura [0000-0002-0241-1810]
dc.contributor.orcidGomes, Denise Molina [0000-0002-2836-9008]
dc.contributor.orcidNevanlinna, Heli [0000-0002-0916-2976]
dc.contributor.orcidOlopade, Olufunmilayo I [0000-0002-9936-1599]
dc.contributor.orcidPalli, Domenico [0000-0002-5558-2437]
dc.contributor.orcidPark, Sue K [0000-0001-5002-9707]
dc.contributor.orcidParsons, Michael T [0000-0003-3242-8477]
dc.contributor.orcidPeterlongo, Paolo [0000-0001-6951-6855]
dc.contributor.orcidPetersen, Annabeth Høgh [0000-0002-4503-6942]
dc.contributor.orcidPujana, Miguel Angel [0000-0003-3222-4044]
dc.contributor.orcidRuddy, Kathryn J [0000-0001-6298-332X]
dc.contributor.orcidScarpitta, Rosa [0000-0001-7590-3827]
dc.contributor.orcidShah, Payal D [0000-0001-5874-3390]
dc.contributor.orcidSilvestri, Valentina [0000-0003-0712-9379]
dc.contributor.orcidSouthey, Melissa C [0000-0002-6313-9005]
dc.contributor.orcidSpurdle, Amanda B [0000-0003-1337-7897]
dc.contributor.orcidStoppa-Lyonnet, Dominique [0000-0002-5438-8309]
dc.contributor.orcidSunde, Lone [0000-0002-8479-165X]
dc.contributor.orcidTeixeira, Manuel R [0000-0002-4896-5982]
dc.contributor.orcidTeo, Soo Hwang [0000-0002-0444-590X]
dc.contributor.orcidTischkowitz, Marc [0000-0002-7880-0628]
dc.contributor.orcidTommasi, Stefania [0000-0002-2157-2978]
dc.contributor.orcidToss, Angela [0000-0002-1854-6701]
dc.contributor.orcidvan der Luijt, Rob B [0000-0002-0018-1089]
dc.contributor.orcidVierstraete, Jeroen [0000-0001-7909-6620]
dc.contributor.orcidWieme, Greet [0000-0003-2718-5300]
dc.contributor.orcidYadav, Siddhartha [0000-0003-4630-9903]
dc.contributor.orcidAntoniou, Antonis [0000-0001-9223-3116]
dc.identifier.eissn1538-7445
rioxxterms.typeJournal Article/Review
pubs.funder-project-idCancer Research UK (20861)
pubs.funder-project-idNational Cancer Institute (U19CA148537)
pubs.funder-project-idNational Cancer Institute (U19CA148065)
pubs.funder-project-idCancer Research UK (CRUK-A12014)
pubs.funder-project-idNational Cancer Institute (R01CA128978)
pubs.funder-project-idWellcome Trust (203477/Z/16/Z)
cam.issuedOnline2019-11-13
cam.orpheus.successThu Jan 30 10:37:49 GMT 2020 - Embargo updated
rioxxterms.freetoread.startdate2020-11-13


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