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dc.contributor.authorSchmaal, Lianne
dc.contributor.authorvan Harmelen, Anne-Laura
dc.contributor.authorChatzi, Vasiliki
dc.contributor.authorLippard, Elizabeth TC
dc.contributor.authorToenders, Yara J
dc.contributor.authorAverill, Lynnette A
dc.contributor.authorMazure, Carolyn M
dc.contributor.authorBlumberg, Hilary P
dc.date.accessioned2019-10-29T00:31:07Z
dc.date.available2019-10-29T00:31:07Z
dc.date.issued2020-02
dc.identifier.issn1359-4184
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/298133
dc.description.abstractIdentifying brain alterations that contribute to suicidal thoughts and behaviors (STBs) are important to develop more targeted and effective strategies to prevent suicide. In the last decade, and especially in the last 5 years, there has been exponential growth in the number of neuroimaging studies reporting structural and functional brain circuitry correlates of STBs. Within this narrative review, we conducted a comprehensive review of neuroimaging studies of STBs published to date and summarize the progress achieved on elucidating neurobiological substrates of STBs, with a focus on converging findings across studies. We review neuroimaging evidence across differing mental disorders for structural, functional, and molecular alterations in association with STBs, which converges particularly in regions of brain systems that subserve emotion and impulse regulation including the ventral prefrontal cortex (VPFC) and dorsal PFC (DPFC), insula and their mesial temporal, striatal and posterior connection sites, as well as in the connections between these brain areas. The reviewed literature suggests that impairments in medial and lateral VPFC regions and their connections may be important in the excessive negative and blunted positive internal states that can stimulate suicidal ideation, and that impairments in a DPFC and inferior frontal gyrus (IFG) system may be important in suicide attempt behaviors. A combination of VPFC and DPFC system disturbances may lead to very high risk circumstances in which suicidal ideation is converted to lethal actions via decreased top-down inhibition of behavior and/or maladaptive, inflexible decision-making and planning. The dorsal anterior cingulate cortex and insula may play important roles in switching between these VPFC and DPFC systems, which may contribute to the transition from suicide thoughts to behaviors. Future neuroimaging research of larger sample sizes, including global efforts, longitudinal designs, and careful consideration of developmental stages, and sex and gender, will facilitate more effectively targeted preventions and interventions to reduce loss of life to suicide.
dc.description.sponsorshipThis work was supported by the MQ Brighter Futures Award MQBFC/2 (ALvH, HB, LS), by the National Institute of Mental Health of the National Institutes of Health under Award Number R01MH117601 (LS), RC1MH088366 (HPB), R01MH113230 (HPB), R61MH111929 (HPB), T32MH014276 (ETCL), and T32DA022975 (ETCL). LS is supported by a NHMRC Career Development Fellowship (1140764). ALVH is supported by a Royal Society Dorothy Hodgkin Fellowship (DH15017). LAA is supported by the American Foundation for Suicide Prevention, Brain and Behavior Foundation/NARSAD, Robert E. Leet and Clara M. Guthrie Patterson Trust, and Department of Veterans Affairs. HPB is supported by the American Foundation for Suicide Prevention and For the Love of Travis Foundation.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAll rights reserved
dc.subjectBrain
dc.subjectGyrus Cinguli
dc.subjectPrefrontal Cortex
dc.subjectHumans
dc.subjectSuicide
dc.subjectSuicide, Attempted
dc.subjectEmotions
dc.subjectMental Disorders
dc.subjectFemale
dc.subjectMale
dc.subjectSuicidal Ideation
dc.subjectNeuroimaging
dc.titleImaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies.
dc.typeArticle
prism.endingPage427
prism.issueIdentifier2
prism.publicationDate2020
prism.publicationNameMol Psychiatry
prism.startingPage408
prism.volume25
dc.identifier.doi10.17863/CAM.45190
dcterms.dateAccepted2019-10-29
rioxxterms.versionofrecord10.1038/s41380-019-0587-x
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2020-02
dc.contributor.orcidvan Harmelen, Anne-Laura [0000-0003-1108-2921]
dc.identifier.eissn1476-5578
rioxxterms.typeJournal Article/Review
pubs.funder-project-idRoyal Society (DH150176)
pubs.funder-project-idMQ: Transforming Mental Health (Unknown)
cam.issuedOnline2019-12-02
cam.orpheus.successThu Jan 30 10:36:32 GMT 2020 - Embargo updated
rioxxterms.freetoread.startdate2020-06-02


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