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dc.contributor.authorValabhji, Jonathanen
dc.contributor.authorBarron, Emmaen
dc.contributor.authorBradley, Dominiqueen
dc.contributor.authorBakhai, Chiragen
dc.contributor.authorFagg, Jamieen
dc.contributor.authorO'Neill, Simonen
dc.contributor.authorYoung, Boben
dc.contributor.authorWareham, Nicholasen
dc.contributor.authorKhunti, Kamleshen
dc.contributor.authorJebb, Susanen
dc.contributor.authorSmith, Jeniferen
dc.date.accessioned2019-10-29T00:31:45Z
dc.date.available2019-10-29T00:31:45Z
dc.date.issued2020-01en
dc.identifier.issn0149-5992
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/298158
dc.description.abstractObjective To assess weight and HbA1c changes in the Healthier You: National Health Service Diabetes Prevention Programme (NHS DPP), the largest DPP globally to achieve universal population coverage. Research Design and Methods A service evaluation assessing intervention effectiveness for adults with non-diabetic hyperglycaemia (HbA1c 42-47 mmol/mol (6.0-6.4%)) or fasting plasma glucose 5.5-6.9 mmol/l) between programme launch in June 2016 and December 2018, using prospectively collected national service-level data in England. Results By December 2018, 324,699 people had been referred, 152,294 had attended initial assessment and 96,442 had attended at least one of 13 group-based intervention sessions. Allowing sufficient time to elapse: 53% attended initial assessment; 36% attended at least one group-based session; and 19% completed the intervention (attended over 60% of sessions). Of the 32,665 that attended at least one intervention session and had sufficient time to finish, 17,252 (53%) completed: intention-to-treat analyses demonstrated mean weight loss 2.3 (95% CI: 2.2-2.3) kg and HbA1c reduction 1.26 (1.20-1.31) mmol/mol (0.12 (0.11-0.12) %); completer analysis demonstrated mean weight loss 3.3 (3.2-3.4) kg and HbA1c reduction 2.04 (1.96-2.12) mmol/mol (0.19 (0.18-0.19) %). Younger age, female sex, Asian and black ethnicity, lower socioeconomic status and normal baseline BMI were associated with less weight loss. Older age, female sex, black ethnicity, lower socioeconomic status and baseline overweight and obesity were associated with smaller HbA1c reduction. Conclusions Reductions in weight and HbA1c compare favourably to those reported in recent meta-analyses of pragmatic studies and suggest likely future reductions in participant type 2 diabetes incidence
dc.description.sponsorshipNHS England funded programme development, implementation and evaluation.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectHumansen
dc.subjectDiabetes Mellitus, Type 2en
dc.subjectPrediabetic Stateen
dc.subjectHyperglycemiaen
dc.subjectObesityen
dc.subjectWeight Lossen
dc.subjectPreventive Medicineen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectMiddle Ageden
dc.subjectPreventive Health Servicesen
dc.subjectState Medicineen
dc.subjectEnglanden
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectWeight Reduction Programsen
dc.subjectOutcome Assessment, Health Careen
dc.titleEarly Outcomes From the English National Health Service Diabetes Prevention Programme.en
dc.typeArticle
prism.endingPage160
prism.issueIdentifier1en
prism.publicationDate2020en
prism.publicationNameDiabetes careen
prism.startingPage152
prism.volume43en
dc.identifier.doi10.17863/CAM.45215
dcterms.dateAccepted2019-10-22en
rioxxterms.versionofrecord10.2337/dc19-1425en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2020-01en
dc.contributor.orcidValabhji, Jonathan [0000-0001-9756-4061]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.contributor.orcidKhunti, Kamlesh [0000-0003-2343-7099]
dc.contributor.orcidJebb, Susan [0000-0001-9190-2920]
dc.identifier.eissn1935-5548
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_12015/1)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
cam.orpheus.successTue Mar 31 10:39:00 BST 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-01-31


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