Show simple item record

dc.contributor.authorPaquola, Caseyen
dc.contributor.authorBethlehem, Richarden
dc.contributor.authorSeidlitz, Jakoben
dc.contributor.authorWagstyl, Konraden
dc.contributor.authorRomero-Garcia, Rafaelen
dc.contributor.authorWhitaker, Kirstieen
dc.contributor.authorVos de Wael, Reinderen
dc.contributor.authorWilliams, Guyen
dc.contributor.authorNSPN Consortium,en
dc.contributor.authorVertes, Petraen
dc.contributor.authorMargulies, Daniel Sen
dc.contributor.authorBernhardt, Borisen
dc.contributor.authorBullmore, Edwarden
dc.date.accessioned2019-11-05T00:30:50Z
dc.date.available2019-11-05T00:30:50Z
dc.date.issued2019-11-14en
dc.identifier.issn2050-084X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/298698
dc.description.abstractWe studied an accelerated longitudinal cohort of adolescents and young adults (n=223, two time points) to investigate dynamic reconfigurations in myeloarchitecture. Intracortical profiles were generated using magnetization transfer (MT) data, a myelin-sensitive magnetic resonance imaging contrast. Mixed-effect models of depth specific intracortical profiles demonstrated two separate processes i) overall increases in MT, and ii) flattening of the MT profile related to enhanced signal in mid-to-deeper layers, especially in heteromodal and unimodal association cortices. This development was independent of morphological changes. Enhanced MT in mid-to-deeper layers was found to spatially co-localise specifically with gene expression markers of oligodendrocytes. Interregional covariance analysis revealed that these intracortical changes contributed to a gradual differentiation of higher-order from lower-order systems. Depth-dependent trajectories of intracortical myeloarchitectural development contribute to the maturation of structural hierarchies in the human neocortex, providing a model for adolescent development that bridges microstructural and macroscopic scales of brain organisation.
dc.description.sponsorshipMRC, Wellcome Trust, Cambridge-MNI exhchange, Guarantors of Brain, Alan Turing Institute, NSERC, CIHR, ACAR, NIHR
dc.format.mediumElectronicen
dc.languageengen
dc.publishereLife Sciences Publications Ltd
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectNSPN Consortiumen
dc.subjectCerebral Cortexen
dc.subjectHumansen
dc.subjectMagnetic Resonance Imagingen
dc.subjectLongitudinal Studiesen
dc.subjectAdolescent Developmenten
dc.subjectSurface Propertiesen
dc.subjectModels, Neurologicalen
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectYoung Adulten
dc.subjectHealthy Volunteersen
dc.titleShifts in myeloarchitecture characterise adolescent development of cortical gradients.en
dc.typeArticle
prism.publicationDate2019en
prism.publicationNameeLifeen
prism.volume8en
dc.identifier.doi10.17863/CAM.45755
dcterms.dateAccepted2019-11-02en
rioxxterms.versionofrecord10.7554/elife.50482en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-11-14en
dc.contributor.orcidPaquola, Casey [0000-0002-0190-4103]
dc.contributor.orcidBethlehem, Richard [0000-0002-0714-0685]
dc.contributor.orcidSeidlitz, Jakob [0000-0002-8164-7476]
dc.contributor.orcidRomero-Garcia, Rafael [0000-0002-5199-4573]
dc.contributor.orcidWhitaker, Kirstie [0000-0001-8498-4059]
dc.contributor.orcidWilliams, Guy [0000-0001-5223-6654]
dc.contributor.orcidVértes, Petra [0000-0002-0992-3210]
dc.contributor.orcidBernhardt, Boris [0000-0001-9256-6041]
dc.contributor.orcidBullmore, Edward [0000-0002-8955-8283]
dc.identifier.eissn2050-084X
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBritish Academy (PFO\170517)
pubs.funder-project-idSocial Sciences and Humanities Research Council of Canada (SSHRC) (via McGill University) (Unknown)
pubs.funder-project-idWellcome Trust (095844/Z/11/Z)
pubs.funder-project-idAlan Turing Institute (AT/120001/005)
pubs.funder-project-idMRC (MR/K020706/1)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (MR/M009041/1)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (MR/M024873/1)
pubs.funder-project-idMQ: Transforming Mental Health (MQ17-24 Vertes)
rioxxterms.freetoread.startdate2022-11-04


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record