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dc.contributor.authorLindner, Oana Cen
dc.contributor.authorMayes, Andrewen
dc.contributor.authorMcCabe, Martin Gen
dc.contributor.authorTalmi, Deborahen
dc.date.accessioned2019-11-23T00:31:12Z
dc.date.available2019-11-23T00:31:12Z
dc.date.issued2017-11en
dc.identifier.issn0965-8211
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/299179
dc.description.abstractData from research on amnesia and epilepsy are equivocal with regards to the dissociation, shown in animal models, between rapid and slow long-term memory consolidation. Cancer treatments have lasting disruptive effects on memory and on brain structures associated with memory, but their acute effects on synaptic consolidation are unknown. We investigated the hypothesis that cancer treatment selectively impairs slow synaptic consolidation. Cancer patients and their matched controls were administered a novel list-learning task modelled on the Rey Auditory Verbal Learning Test. Learning, forgetting, and retrieval were tested before, and one day after patients' first chemotherapy treatment. Due to difficulties recruiting cancer patients at that sensitive time, we were only able to study 10 patients and their matched controls. Patients exhibited treatment-dependent accelerated forgetting over 24 hours compared to their own pre-treatment performance and to the performance of control participants, in agreement with our hypothesis. The number of intrusions increased after treatment, suggesting retrieval deficits. Future research with larger samples should adapt our methods to distinguish between consolidation and retrieval causes for treatment-dependent accelerated forgetting. The presence of significant accelerated forgetting in our small sample is indicative of a potentially large acute effect of chemotherapy treatment on forgetting, with potentially clinically relevant implications.
dc.languageengen
dc.publisherTaylor and Francis
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectMemoryen
dc.subjectcanceren
dc.subjectchemotherapyen
dc.subjectcognitionen
dc.subjectforgettingen
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAmnesiaen
dc.subjectCase-Control Studiesen
dc.subjectDrug Therapyen
dc.subjectDrug-Related Side Effects and Adverse Reactionsen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMemory Disordersen
dc.subjectMental Recallen
dc.subjectMiddle Ageden
dc.subjectNeuropsychological Testsen
dc.subjectVerbal Learningen
dc.subjectYoung Adulten
dc.titleAcute memory deficits in chemotherapy-treated adults.en
dc.typeArticle
prism.endingPage1339
prism.issueIdentifier10en
prism.publicationDate2017en
prism.publicationNameMemoryen
prism.startingPage1327
prism.volume25en
dc.identifier.doi10.17863/CAM.46244
dcterms.dateAccepted2017-02-23en
rioxxterms.versionofrecord10.1080/09658211.2017.1300667en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-11en
dc.contributor.orcidTalmi, Deborah [0000-0002-7720-2706]
dc.identifier.eissn1464-0686
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2017-03-13en
dc.identifier.urlhttps://www.tandfonline.com/doi/full/10.1080/09658211.2017.1300667en
rioxxterms.freetoread.startdate2018-11-30


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