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dc.contributor.authorSchiller, Herbert Ben
dc.contributor.authorMontoro, Daniel Ten
dc.contributor.authorSimon, Lukas Men
dc.contributor.authorRawlins, Emmaen
dc.contributor.authorMeyer, Kerstinen
dc.contributor.authorStrunz, Maximilianen
dc.contributor.authorVieira Braga, Felipe Aen
dc.contributor.authorTimens, Wimen
dc.contributor.authorKoppelman, Gerard Hen
dc.contributor.authorBudinger, GR Scotten
dc.contributor.authorBurgess, Janette Ken
dc.contributor.authorWaghray, Avinashen
dc.contributor.authorvan den Berge, Maartenen
dc.contributor.authorTheis, Fabian Jen
dc.contributor.authorRegev, Aviven
dc.contributor.authorKaminski, Naftalien
dc.contributor.authorRajagopal, Jayarajen
dc.contributor.authorTeichmann, Sarahen
dc.contributor.authorMisharin, Alexander Ven
dc.contributor.authorNawijn, Martijn Cen
dc.date.accessioned2019-12-12T14:19:21Z
dc.date.available2019-12-12T14:19:21Z
dc.date.issued2019-07-01en
dc.identifier.issn1044-1549
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/299823
dc.description.abstractLung disease accounts for every sixth death globally. Profiling the molecular state of all lung cell types in health and disease is currently revolutionizing the identification of disease mechanisms and will aid the design of novel diagnostic and personalized therapeutic regimens. Recent progress in high-throughput techniques for single-cell genomic and transcriptomic analyses has opened up new possibilities to study individual cells within a tissue, classify these into cell types, and characterize variations in their molecular profiles as a function of genetics, environment, cell-cell interactions, developmental processes, aging, or disease. Integration of these cell state definitions with spatial information allows the in-depth molecular description of cellular neighborhoods and tissue microenvironments, including the tissue resident structural and immune cells, the tissue matrix, and the microbiome. The Human Cell Atlas consortium aims to characterize all cells in the healthy human body and has prioritized lung tissue as one of the flagship projects. Here, we present the rationale, the approach, and the expected impact of a Human Lung Cell Atlas.
dc.description.sponsorshipSupported by the Helmholtz Association and the German Center for Lung Research (DZL) (H.B.S.); the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement 753039 (L.M.S.); U.K. Medical Research Council grant G0900424 (E.L.R.); National Institutes of Health (NIH) grants ES013995, HL071643, and AG049665, and Veterans Administration grant BX000201 and Department of Defense grant PR141319 (G.R.S.B.); NIH grants HL135124 and AI135964 and Department of Defense grant PR141319 (A.V.M.); NIH grants R01HL141852, R01HL127349, UHHL3123886, U01HL122626, and UG3TR002445, and Department of Defence grant PR151124 (N.K.); and the Netherlands Lung Foundation grants 5.1.14.020 and 4.1.18.226 (M.C.N.).
dc.languageengen
dc.publisherAmerican Thoracic Society
dc.subjectHuman Cell Atlasen
dc.subjectsingle-cell RNA sequencingen
dc.subjectspatial transcriptomicsen
dc.subjectsystems biologyen
dc.titleThe Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease.en
dc.typeArticle
prism.endingPage41
prism.issueIdentifier1en
prism.publicationDate2019en
prism.publicationNameAmerican Journal of Respiratory Cell and Molecular Biologyen
prism.startingPage31
prism.volume61en
dc.identifier.doi10.17863/CAM.46893
dcterms.dateAccepted2019-04-17en
rioxxterms.versionofrecord10.1165/rcmb.2018-0416TRen
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-07-01en
dc.contributor.orcidRawlins, Emma [0000-0001-7426-3792]
dc.contributor.orcidMeyer, Kerstin [0000-0001-5906-1498]
dc.contributor.orcidTeichmann, Sarah [0000-0002-6294-6366]
dc.identifier.eissn1535-4989
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MR/P009581/1)
pubs.funder-project-idMRC (MR/S035907/1)
pubs.funder-project-idMRC (G0900424)
cam.issuedOnline2019-04-17en
cam.orpheus.successThu Jan 30 10:33:54 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-04-17


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