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dc.contributor.authorMiska, Ericen
dc.contributor.authorFerguson-Smith, Anneen
dc.date.accessioned2020-01-04T00:30:38Z
dc.date.available2020-01-04T00:30:38Z
dc.date.issued2016-10en
dc.identifier.issn0036-8075
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/300386
dc.description.abstractHeritability has traditionally been thought to be a characteristic feature of the genetic material of an organism-notably, its DNA. However, it is now clear that inheritance not based on DNA sequence exists in multiple organisms, with examples found in microbes, plants, and invertebrate and vertebrate animals. In mammals, the molecular mechanisms have been challenging to elucidate, in part due to difficulties in designing robust models and approaches. Here we review some of the evidence, concepts, and potential mechanisms of non-DNA sequence-based transgenerational inheritance. We highlight model systems and discuss whether phenotypes are replicated or reconstructed over successive generations, as well as whether mechanisms operate at transcriptional and/or posttranscriptional levels. Finally, we explore the short- and long-term implications of non-DNA sequence-based inheritance. Understanding the effects of non-DNA sequence-based mechanisms is key to a full appreciation of heritability in health and disease.
dc.format.mediumPrinten
dc.languageengen
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectFlowersen
dc.subjectDiseaseen
dc.subjectHistonesen
dc.subjectDNAen
dc.subjectRNA, Untranslateden
dc.subjectAdaptation, Biologicalen
dc.subjectEvolution, Molecularen
dc.subjectDNA Replicationen
dc.subjectEpigenesis, Geneticen
dc.subjectProtein Processing, Post-Translationalen
dc.subjectHeredityen
dc.subjectBase Sequenceen
dc.subjectAllelesen
dc.subjectModels, Geneticen
dc.titleTransgenerational inheritance: Models and mechanisms of non-DNA sequence-based inheritance.en
dc.typeArticle
prism.endingPage63
prism.issueIdentifier6308en
prism.publicationDate2016en
prism.publicationNameScience (New York, N.Y.)en
prism.startingPage59
prism.volume354en
dc.identifier.doi10.17863/CAM.47460
dcterms.dateAccepted2016-10-07en
rioxxterms.versionofrecord10.1126/science.aaf4945en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-10en
dc.contributor.orcidMiska, Eric [0000-0002-4450-576X]
dc.contributor.orcidFerguson-Smith, Anne [0000-0002-7608-5894]
dc.identifier.eissn1095-9203
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MR/J001597/1)
pubs.funder-project-idWellcome Trust (095606/Z/11/Z)
pubs.funder-project-idWellcome Trust (092096/Z/10/Z)
pubs.funder-project-idWELLCOME TRUST (104640/Z/14/Z)
pubs.funder-project-idCancer Research UK (18583)
pubs.funder-project-idCancer Research UK (A14492)


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