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dc.contributor.authorChugh, Priyamvadaen
dc.contributor.authorPaluch, Ewa Kamilaen
dc.date.accessioned2020-07-02T23:30:57Z
dc.date.available2020-07-02T23:30:57Z
dc.date.issued2018-07-19en
dc.identifier.issn0021-9533
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/307535
dc.description.abstractPrecisely controlled cell deformations are key to cell migration, division and tissue morphogenesis, and have been implicated in cell differentiation during development, as well as cancer progression. In animal cells, shape changes are primarily driven by the cellular cortex, a thin actomyosin network that lies directly underneath the plasma membrane. Myosin-generated forces create tension in the cortical network, and gradients in tension lead to cellular deformations. Recent studies have provided important insight into the molecular control of cortical tension by progressively unveiling cortex composition and organization. In this Cell Science at a Glance article and the accompanying poster, we review our current understanding of cortex composition and architecture. We then discuss how the microscopic properties of the cortex control cortical tension. While many open questions remain, it is now clear that cortical tension can be modulated through both cortex composition and organization, providing multiple levels of regulation for this key cellular property during cell and tissue morphogenesis.
dc.format.mediumElectronicen
dc.languageengen
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAnimalsen
dc.subjectHumansen
dc.subjectActinsen
dc.subjectMyosinsen
dc.subjectCell Shapeen
dc.subjectActin Cytoskeletonen
dc.titleThe actin cortex at a glance.en
dc.typeArticle
prism.issueIdentifier14en
prism.publicationDate2018en
prism.publicationNameJournal of cell scienceen
prism.volume131en
dc.identifier.doi10.17863/CAM.54625
rioxxterms.versionofrecord10.1242/jcs.186254en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-07-19en
dc.contributor.orcidChugh, Priyamvada [0000-0001-5378-5874]
dc.contributor.orcidPaluch, Ewa [0000-0003-4691-2323]
dc.identifier.eissn1477-9137
rioxxterms.typeJournal Article/Reviewen


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International