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dc.contributor.authorFunston, Garthen
dc.contributor.authorMounce, Luke Taen
dc.contributor.authorPrice, Sarahen
dc.contributor.authorRous, Brianen
dc.contributor.authorCrosbie, Emma Jen
dc.contributor.authorHamilton, Willieen
dc.contributor.authorWalter, Fionaen
dc.date.accessioned2021-02-11T15:53:45Z
dc.date.available2021-02-11T15:53:45Z
dc.date.issued2021-06en
dc.identifier.issn0960-1643
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/317491
dc.description.abstractBackground Cancer-Antigen-125 (CA125) is recommended as a first-line investigation in women in UK General Practice with symptoms of possible ovarian cancer. Aim To compare time between initial primary care CA125 test and diagnosis (test-to-diagnosis interval), tumour morphology and stage, in women with normal (<35U/ml) and abnormal (≥35U/ml) CA125 prior to ovarian cancer diagnosis. Design Retrospective cohort study using routinely collected primary care and cancer registry data. Methods Associations between CA125 result with test-to-diagnosis interval, stage and ovarian cancer morphology were examined. Results 351 (77%) women had an abnormal and 105 (23%) a normal initial CA125 result prior to ovarian cancer diagnosis. Median test-to-diagnosis interval was 35 days (Interquartile range [IQR]:21-53) in those with abnormal, and 64 days (IQR:42-127) in those with normal CA125s. Tumour morphology differed by CA125 result, with indolent borderline tumours being less common in those with abnormal (n=47, 13%) than normal (n=51, 49%) CA125s (p<0.001). Staging data was available for 381 women. 106 of 304 (35%) women with abnormal CA125s and 66 of 77 (86%) women with normal CA125s were diagnosed at an early stage: normal CA125s were associated with early-stage diagnosis (Odds Ratio:12.1, 95% CI:5.8-25.1, p<0.001). Conclusion Despite experiencing longer intervals between testing and diagnosis, women with normal CA125s more frequently had indolent tumours and were more commonly diagnosed at an early stage,
dc.description.sponsorshipCRUK
dc.format.mediumElectronic-Printen
dc.languageengen
dc.publisherRoyal College of General Practitioners
dc.rightsAll rights reserved
dc.subjectHumansen
dc.subjectOvarian Neoplasmsen
dc.subjectCA-125 Antigenen
dc.subjectRetrospective Studiesen
dc.subjectPrimary Health Careen
dc.subjectFemaleen
dc.subjectElectronic Health Recordsen
dc.titleCA125 test result, test-to-diagnosis interval, and stage in ovarian cancer at diagnosis: a retrospective cohort study using electronic health records.en
dc.typeArticle
prism.endingPagee472
prism.issueIdentifier707en
prism.publicationDate2021en
prism.publicationNameThe British journal of general practice : the journal of the Royal College of General Practitionersen
prism.startingPagee465
prism.volume71en
dc.identifier.doi10.17863/CAM.64607
dcterms.dateAccepted2020-12-02en
rioxxterms.versionofrecord10.3399/bjgp.2020.0859en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2021-06en
dc.contributor.orcidFunston, Garth [0000-0002-4156-6401]
dc.contributor.orcidCrosbie, Emma J [0000-0003-0284-8630]
dc.contributor.orcidWalter, Fiona [0000-0002-7191-6476]
dc.identifier.eissn1478-5242
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idCancer Research UK (23385)
cam.orpheus.successMon Feb 15 07:30:24 GMT 2021 - Embargo updated*
rioxxterms.freetoread.startdate2022-02-03


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