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dc.contributor.authorWestwater-Wozniak, Margareten
dc.contributor.authorMancini, Flaviaen
dc.contributor.authorGorka, Adam Xen
dc.contributor.authorShapleske, Janeen
dc.contributor.authorSerfontein, Jacoen
dc.contributor.authorGrillon, Christianen
dc.contributor.authorErnst, Moniqueen
dc.contributor.authorZiauddeen, Hishamen
dc.contributor.authorFletcher, Paulen
dc.date.accessioned2021-03-06T00:30:30Z
dc.date.available2021-03-06T00:30:30Z
dc.date.issued2021-05en
dc.identifier.issn0270-6474
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/318462
dc.description.abstractBinge-eating is a distressing, transdiagnostic eating disorder symptom associated with impulsivity, particularly in negative mood states. Neuroimaging studies of bulimia nervosa (BN) report reduced activity in fronto-striatal regions implicated in self-regulatory control, and an influential theory posits that binge-eating results from self-regulation failures under stress. However, there is no direct evidence that psychological stress impairs self-regulation in binge-eating disorders, or that any such self-regulatory deficits generalize to binge-eating in underweight individuals (i.e., the anorexia nervosa bingeing/purging subtype; AN-BP). We therefore determined the effect of acute stress on inhibitory control in 85 women (33 BN, 22 AN-BP, 30 controls). Participants underwent repeated functional MRI scanning, during performance of the stop-signal anticipation task, a validated measure of proactive (i.e., anticipation of stopping) and reactive (outright stopping) inhibition. Neural and behavioral responses to induced stress and a control task were evaluated on two, consecutive days. Women with BN had reduced proactive inhibition while prefrontal responses were increased in both AN-BP and BN. Reactive inhibition was neurally and behaviorally intact in both diagnostic groups. Both AN-BP and BN groups showed distinct, stress-induced changes in inferior and superior frontal activity during both proactive and reactive inhibition. However, task performance was unaffected by stress. These results offer novel evidence of reduced proactive inhibition in BN, yet inhibitory control deficits did not generalize to AN-BP. Our findings identify intriguing alterations of stress responses and inhibitory function associated with binge-eating, but they counsel against stress-induced failures of inhibitory control as a comprehensive explanation for loss-of-control eating.
dc.description.sponsorshipFunding was provided by the Bernard Wolfe Health Neuroscience Fund to PCF and HZ and a Wellcome Trust Investigator Award to PCF (Reference No. 206368/Z/17/Z). MLW was supported through the NIH-Oxford-Cambridge Scholars Program and a Cambridge Trust fellowship. FM was supported by research grants from Versus Arthritis, the Experimental Psychological Society and a Career Development Award from the Medical Research Council (MR/T010614/1). AG, CG and ME were supported by the Intramural Research Program of the NIMH (Ref. ZIAMH002798). The Wellcome Trust/NIHR Clinical and Translational Research Facilities and the Wolfson Brain Imaging Centre provided equipment and support staff for the study. This research was supported by the NIHR Cambridge Biomedical Research Centre (BRC-1215-20014).
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherSociety for Neuroscience
dc.rightsAll rights reserved
dc.rights.uri
dc.titlePrefrontal Responses during Proactive and Reactive Inhibition Are Differentially Impacted by Stress in Anorexia and Bulimia Nervosa.en
dc.typeArticle
prism.endingPage4499
prism.issueIdentifier20en
prism.publicationDate2021en
prism.publicationNameThe Journal of neuroscience : the official journal of the Society for Neuroscienceen
prism.startingPage4487
prism.volume41en
dc.identifier.doi10.17863/CAM.65576
dcterms.dateAccepted2021-03-02en
rioxxterms.versionofrecord10.1523/jneurosci.2853-20.2021en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2021-05en
dc.contributor.orcidWestwater, Margaret [0000-0002-2918-0979]
dc.contributor.orcidMancini, Flavia [0000-0001-8441-9236]
dc.contributor.orcidZiauddeen, Hisham [0000-0003-4044-1719]
dc.contributor.orcidFletcher, Paul [0000-0001-8257-1517]
dc.identifier.eissn1529-2401
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (100574/Z/12/Z)
pubs.funder-project-idWellcome Trust (206368/Z/17/Z)
pubs.funder-project-idWellcome Trust (100574/B/12/Z)
cam.orpheus.successMon Apr 19 07:30:46 BST 2021 - Embargo updated*
cam.orpheus.counter6*
rioxxterms.freetoread.startdate2021-10-12


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