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dc.contributor.authorPark, JooYong
dc.contributor.authorChoi, Ji-Yeob
dc.contributor.authorChoi, Jaesung
dc.contributor.authorChung, Seokang
dc.contributor.authorSong, Nan
dc.contributor.authorPark, Sue K
dc.contributor.authorHan, Wonshik
dc.contributor.authorNoh, Dong-Young
dc.contributor.authorAhn, Sei-Hyun
dc.contributor.authorLee, Jong Won
dc.contributor.authorKim, Mi Kyung
dc.contributor.authorJee, Sun Ha
dc.contributor.authorWen, Wanqing
dc.contributor.authorBolla, Manjeet K
dc.contributor.authorWang, Qin
dc.contributor.authorDennis, Joe
dc.contributor.authorMichailidou, Kyriaki
dc.contributor.authorShah, Mitul
dc.contributor.authorConroy, Don M
dc.contributor.authorHarrington, Patricia A
dc.contributor.authorMayes, Rebecca
dc.contributor.authorCzene, Kamila
dc.contributor.authorHall, Per
dc.contributor.authorTeras, Lauren R
dc.contributor.authorPatel, Alpa V
dc.contributor.authorCouch, Fergus J
dc.contributor.authorOlson, Janet E
dc.contributor.authorSawyer, Elinor J
dc.contributor.authorRoylance, Rebecca
dc.contributor.authorBojesen, Stig E
dc.contributor.authorFlyger, Henrik
dc.contributor.authorLambrechts, Diether
dc.contributor.authorBaten, Adinda
dc.contributor.authorMatsuo, Keitaro
dc.contributor.authorIto, Hidemi
dc.contributor.authorGuénel, Pascal
dc.contributor.authorTruong, Thérèse
dc.contributor.authorKeeman, Renske
dc.contributor.authorSchmidt, Marjanka K
dc.contributor.authorWu, Anna H
dc.contributor.authorTseng, Chiu-Chen
dc.contributor.authorCox, Angela
dc.contributor.authorCross, Simon S
dc.contributor.authorkConFab Investigators
dc.contributor.authorAndrulis, Irene L
dc.contributor.authorHopper, John L
dc.contributor.authorSouthey, Melissa C
dc.contributor.authorWu, Pei-Ei
dc.contributor.authorShen, Chen-Yang
dc.contributor.authorFasching, Peter A
dc.contributor.authorEkici, Arif B
dc.contributor.authorMuir, Kenneth
dc.contributor.authorLophatananon, Artitaya
dc.contributor.authorBrenner, Hermann
dc.contributor.authorArndt, Volker
dc.contributor.authorJones, Michael E
dc.contributor.authorSwerdlow, Anthony J
dc.contributor.authorHoppe, Reiner
dc.contributor.authorKo, Yon-Dschun
dc.contributor.authorHartman, Mikael
dc.contributor.authorLi, Jingmei
dc.contributor.authorMannermaa, Arto
dc.contributor.authorHartikainen, Jaana M
dc.contributor.authorBenitez, Javier
dc.contributor.authorGonzález-Neira, Anna
dc.contributor.authorHaiman, Christopher A
dc.contributor.authorDörk, Thilo
dc.contributor.authorBogdanova, Natalia V
dc.contributor.authorTeo, Soo Hwang
dc.contributor.authorMohd Taib, Nur Aishah
dc.contributor.authorFletcher, Olivia
dc.contributor.authorJohnson, Nichola
dc.contributor.authorGrip, Mervi
dc.contributor.authorWinqvist, Robert
dc.contributor.authorBlomqvist, Carl
dc.contributor.authorNevanlinna, Heli
dc.contributor.authorLindblom, Annika
dc.contributor.authorWendt, Camilla
dc.contributor.authorKristensen, Vessela N
dc.contributor.authorNbcs Collaborators
dc.contributor.authorTollenaar, Rob AEM
dc.contributor.authorHeemskerk-Gerritsen, Bernadette AM
dc.contributor.authorRadice, Paolo
dc.contributor.authorBonanni, Bernardo
dc.contributor.authorHamann, Ute
dc.contributor.authorManoochehri, Mehdi
dc.contributor.authorLacey, James V
dc.contributor.authorMartinez, Maria Elena
dc.contributor.authorDunning, Alison
dc.contributor.authorPharoah, Paul
dc.contributor.authorEaston, Douglas
dc.contributor.authorYoo, Keun-Young
dc.contributor.authorKang, Daehee
dc.date.accessioned2021-05-13T23:30:45Z
dc.date.available2021-05-13T23:30:45Z
dc.date.issued2021-05-14
dc.identifier.issn2072-6694
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/322366
dc.description.abstractIn this study we aim to examine gene-environment interactions (GxEs) between genes involved with estrogen metabolism and environmental factors related to estrogen exposure. GxE analyses were conducted with 1970 Korean breast cancer cases and 2052 controls in the case-control study, the Seoul Breast Cancer Study (SEBCS). A total of 11,555 SNPs from the 137 candidate genes were included in the GxE analyses with eight established environmental factors. A replication test was conducted by using an independent population from the Breast Cancer Association Consortium (BCAC), with 62,485 Europeans and 9047 Asians. The GxE tests were performed by using two-step methods in GxEScan software. Two interactions were found in the SEBCS. The first interaction was shown between rs13035764 of NCOA1 and age at menarche in the GE|2df model (p-2df = 1.2 × 10-3). The age at menarche before 14 years old was associated with the high risk of breast cancer, and the risk was higher when subjects had homozygous minor allele G. The second GxE was shown between rs851998 near ESR1 and height in the GE|2df model (p-2df = 1.1 × 10-4). Height taller than 160 cm was associated with a high risk of breast cancer, and the risk increased when the minor allele was added. The findings were not replicated in the BCAC. These results would suggest specificity in Koreans for breast cancer risk.
dc.format.mediumElectronic
dc.languageeng
dc.publisherMDPI AG
dc.rightsAll rights reserved
dc.titleGene-Environment Interactions Relevant to Estrogen and Risk of Breast Cancer: Can Gene-Environment Interactions Be Detected Only among Candidate SNPs from Genome-Wide Association Studies?
dc.typeArticle
prism.issueIdentifier10
prism.publicationDate2021
prism.publicationNameCancers (Basel)
prism.volume13
dc.identifier.doi10.17863/CAM.69825
dcterms.dateAccepted2021-04-30
rioxxterms.versionofrecord10.3390/cancers13102370
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-05-14
dc.contributor.orcidSong, Nan [0000-0002-9182-1060]
dc.contributor.orcidPark, Sue K [0000-0001-5002-9707]
dc.contributor.orcidKim, Mi Kyung [0000-0001-5279-4162]
dc.contributor.orcidDennis, Joe [0000-0003-4591-1214]
dc.contributor.orcidMichailidou, Kyriaki [0000-0001-7065-1237]
dc.contributor.orcidHall, Per [0000-0002-5640-9126]
dc.contributor.orcidMatsuo, Keitaro [0000-0003-1761-6314]
dc.contributor.orcidIto, Hidemi [0000-0002-8023-4581]
dc.contributor.orcidKeeman, Renske [0000-0002-5452-9933]
dc.contributor.orcidSchmidt, Marjanka K [0000-0002-2228-429X]
dc.contributor.orcidFasching, Peter A [0000-0003-4885-8471]
dc.contributor.orcidBrenner, Hermann [0000-0002-6129-1572]
dc.contributor.orcidArndt, Volker [0000-0001-9320-8684]
dc.contributor.orcidHartikainen, Jaana M [0000-0001-8267-1905]
dc.contributor.orcidDörk, Thilo [0000-0002-9458-0282]
dc.contributor.orcidBogdanova, Natalia V [0000-0002-9736-4593]
dc.contributor.orcidJohnson, Nichola [0000-0002-8230-5662]
dc.contributor.orcidNevanlinna, Heli [0000-0002-0916-2976]
dc.contributor.orcidHeemskerk-Gerritsen, Bernadette AM [0000-0002-9724-6693]
dc.contributor.orcidBonanni, Bernardo [0000-0003-3589-2128]
dc.contributor.orcidDunning, Alison [0000-0001-6651-7166]
dc.contributor.orcidPharoah, Paul [0000-0001-8494-732X]
dc.contributor.orcidEaston, Douglas [0000-0003-2444-3247]
dc.identifier.eissn2072-6694
rioxxterms.typeJournal Article/Review
pubs.funder-project-idCancer Research UK (CRUK-A16563)
pubs.funder-project-idCancer Research Uk (None)
cam.issuedOnline2021-05-14
cam.orpheus.counter3
rioxxterms.freetoread.startdate2024-05-12


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