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dc.contributor.authorZaccagna, Fulvio
dc.contributor.authorGaneshan, Balaji
dc.contributor.authorArca, Marcello
dc.contributor.authorRengo, Marco
dc.contributor.authorNapoli, Alessandro
dc.contributor.authorRundo, Leonardo
dc.contributor.authorGroves, Ashley M
dc.contributor.authorLaghi, Andrea
dc.contributor.authorCarbone, Iacopo
dc.contributor.authorMenezes, Leon J
dc.date.accessioned2021-07-12T23:32:35Z
dc.date.available2021-07-12T23:32:35Z
dc.date.issued2021-07
dc.identifier.issn0028-3940
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/325086
dc.description.abstractPURPOSE: To assess the potential role of computed tomography (CT) texture analysis (CTTA) in identifying vulnerable patients with carotid artery atherosclerosis. METHODS: In this case-control pilot study, 12 patients with carotid atherosclerosis and a subsequent history of transient ischemic attack or stroke were age and sex matched with 12 control cases with asymptomatic carotid atherosclerosis (follow-up time 103.58 ± 9.2 months). CTTA was performed using a commercially available research software package (TexRAD) by an operator blinded to clinical data. CTTA comprised a filtration-histogram technique to extract features at different scales corresponding to spatial scale filter (fine = 2 mm, medium = 3 mm, coarse = 4 mm), followed by quantification using histogram-based statistical parameters: mean, kurtosis, skewness, entropy, standard deviation, and mean value of positive pixels. A single axial slice was selected to best represent the largest cross-section of the carotid bifurcation or the greatest degree of stenosis, in presence of an atherosclerotic plaque, on each side. RESULTS: CTTA revealed a statistically significant difference in skewness between symptomatic and asymptomatic patients at the medium (0.22 ± 0.35 vs - 0.18 ± 0.39, p < 0.001) and coarse (0.23 ± 0.22 vs 0.03 ± 0.29, p = 0.003) texture scales. At the fine-texture scale, skewness (0.20 ± 0.59 vs - 0.18 ± 0.58, p = 0.009) and standard deviation (366.11 ± 117.19 vs 300.37 ± 82.51, p = 0.03) were significant before correction. CONCLUSION: Our pilot study highlights the potential of CTTA to identify vulnerable patients in stroke and TIA. CT texture may have the potential to act as a novel risk stratification tool in patients with carotid atherosclerosis.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAll rights reserved
dc.subjectCarotid Arteries
dc.subjectHumans
dc.subjectTomography, X-Ray Computed
dc.subjectCase-Control Studies
dc.subjectPilot Projects
dc.subjectOutcome Assessment, Health Care
dc.titleCT texture-based radiomics analysis of carotid arteries identifies vulnerable patients: a preliminary outcome study.
dc.typeArticle
prism.endingPage1052
prism.issueIdentifier7
prism.publicationDate2021
prism.publicationNameNeuroradiology
prism.startingPage1043
prism.volume63
dc.identifier.doi10.17863/CAM.72541
dcterms.dateAccepted2020-12-17
rioxxterms.versionofrecord10.1007/s00234-020-02628-0
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-07
dc.contributor.orcidZaccagna, Fulvio [0000-0001-6838-9532]
dc.contributor.orcidRundo, Leonardo [0000-0003-3341-5483]
dc.identifier.eissn1432-1920
rioxxterms.typeJournal Article/Review
cam.issuedOnline2021-01-03
cam.orpheus.successMon Jul 19 11:29:45 BST 2021 - Embargo updated
rioxxterms.freetoread.startdate2022-07-31


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