Breakthroughs and bottlenecks in autophagy research.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Mizushima, Noboru
White, Eileen
Rubinsztein, David C
Abstract
The study of autophagy has grown exponentially over the past two decades, and significant progress has been made in our understanding of its mechanisms and physiological significance. However, its application to human diseases remains limited. Here, we summarize the current status of autophagy research, with a particular focus on human diseases.
Description
Keywords
ATG genes, autophagic flux, macroautophagy, neurodegenerative disease, tumor growth, Autophagy, Humans
Journal Title
Trends Mol Med
Conference Name
Journal ISSN
1471-4914
1471-499X
1471-499X
Volume Title
27
Publisher
Elsevier BV
Publisher DOI
Sponsorship
UK Dementia Research Institute (funded by the MRC, Alzheimer’s Research UK and the Alzheimer’s Society), The Tau Consortium, Alzheimer's Research UK and the Roger de Spoelberch Foundation