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dc.contributor.authorSeo, Jen
dc.contributor.authorMatos, J Novoen
dc.contributor.authorPayne, JRen
dc.contributor.authorFuentes, V Luisen
dc.contributor.authorConnolly, DJen
dc.date.accessioned2021-09-23T23:30:24Z
dc.date.available2021-09-23T23:30:24Z
dc.date.issued2021-09-15en
dc.identifier.issn1760-2734
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/328453
dc.description.abstractIntroduction/Objectives: Anterior mitral valve leaflet (AMVL) elongation is a recognised feature of hypertrophic cardiomyopathy (HCM). However, whether AMVL elongation precedes left ventricular hypertrophy (LVH) in cats is currently unknown. The aim of this study was to explore the risk of developing an HCM phenotype in cats with an elongated AMVL. Animals, Materials and Methods: Retrospective longitudinal study. Apparently healthy cats with a normal baseline echocardiogram and a follow-up echocardiogram at >1 year were eligible. Cats at the baseline were grouped based on whether or not they developed HCM phenotype at follow-up. AMVL length and left atrial and left ventricular (LV) dimensions were measured from two-dimensional images. Results: 55 cats were enrolled with a median follow-up period of 5.4 years (25th and 75th quartile, 2.7-6.7). During this time, 17 cats (30.9%) developed an HCM phenotype. At baseline, cats that subsequently developed an HCM phenotype had greater AMVL length (9.4 mm [25th and 75th quartile, 9.0-10.6] vs 8.5 mm [25th and 75th quartile, 7.6-9.1], p < 0.0001) and maximal LV wall thickness (4.5 mm [25th and 75th quartile, 4.1-4.7] vs 4.0 mm [25th and 75th quartile, 3.7-4.6], p = 0.007) than those that did not. Multiple logistic regression analysis confirmed that both baseline variables were independent predictors for development of an HCM phenotype. Conclusions: The AMVL length was greater in cats that subsequently developed LVH. Further studies investigating the clinical application of AMVL in the natural history of feline HCM are warranted.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherElsevier BV
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleAnterior mitral valve leaflet length in cats with hypertrophic cardiomyopathy.en
dc.typeArticle
prism.endingPage70
prism.publicationDate2021en
prism.publicationNameJournal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiologyen
prism.startingPage62
prism.volume37en
dc.identifier.doi10.17863/CAM.75901
dcterms.dateAccepted2021-09-06en
rioxxterms.versionofrecord10.1016/j.jvc.2021.09.001en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2021-09-15en
dc.identifier.eissn1875-0834
rioxxterms.typeJournal Article/Reviewen
cam.orpheus.successMon Sep 27 07:30:20 BST 2021 - Embargo updated*
rioxxterms.freetoread.startdate2022-09-30


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International