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dc.contributor.authorFerris, Mark
dc.contributor.authorFerris, Rebecca
dc.contributor.authorWorkman, Chris
dc.contributor.authorO'Connor, Eoin
dc.contributor.authorEnoch, David A
dc.contributor.authorGoldesgeyme, Emma
dc.contributor.authorQuinnell, Natalie
dc.contributor.authorPatel, Parth
dc.contributor.authorWright, Jo
dc.contributor.authorMartell, Geraldine
dc.contributor.authorMoody, Christine
dc.contributor.authorShaw, Ashley
dc.contributor.authorIllingworth, Christopher
dc.contributor.authorMatheson, Nicholas
dc.contributor.authorWeekes, Michael
dc.date.accessioned2021-11-11T00:30:44Z
dc.date.available2021-11-11T00:30:44Z
dc.date.issued2021-11-16
dc.identifier.issn2050-084X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330556
dc.description.abstractBackground: Respiratory protective equipment recommended in the UK for healthcare workers (HCWs) caring for patients with COVID-19 comprises a fluid-resistant surgical mask (FRSM), except in the context of aerosol generating procedures (AGPs). We previously demonstrated frequent pauci- and asymptomatic severe acute respiratory syndrome coronavirus 2 infection HCWs during the first wave of the COVID-19 pandemic in the UK, using a comprehensive PCR-based HCW screening programme (Rivett et al., 2020; Jones et al., 2020). Methods: Here, we use observational data and mathematical modelling to analyse infection rates amongst HCWs working on 'red' (coronavirus disease 2019, COVID-19) and 'green' (non-COVID-19) wards during the second wave of the pandemic, before and after the substitution of filtering face piece 3 (FFP3) respirators for FRSMs. Results: Whilst using FRSMs, HCWs working on red wards faced an approximately 31-fold (and at least fivefold) increased risk of direct, ward-based infection. Conversely, after changing to FFP3 respirators, this risk was significantly reduced (52-100% protection). Conclusions: FFP3 respirators may therefore provide more effective protection than FRSMs for HCWs caring for patients with COVID-19, whether or not AGPs are undertaken. Funding: Wellcome Trust, Medical Research Council, Addenbrooke's Charitable Trust, NIHR Cambridge Biomedical Research Centre, NHS Blood and Transfusion, UKRI.
dc.languageeng
dc.publishereLife Sciences Publications, Ltd
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectepidemiology
dc.subjectglobal health
dc.subjectinfectious disease
dc.subjectmicrobiology
dc.subjectviruses
dc.titleEfficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers.
dc.typeArticle
prism.publicationDate2021
prism.publicationNameElife
prism.volume10
dc.identifier.doi10.17863/CAM.78000
dcterms.dateAccepted2021-11-07
rioxxterms.versionofrecord10.7554/eLife.71131
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-11-16
dc.contributor.orcidFerris, Mark [0000-0001-5040-4263]
dc.contributor.orcidO'Connor, Eoin [0000-0002-6846-6881]
dc.contributor.orcidIllingworth, Christopher [0000-0002-0030-2784]
dc.contributor.orcidMatheson, Nicholas [0000-0002-3318-1851]
dc.contributor.orcidWeekes, Michael [0000-0003-3196-5545]
dc.identifier.eissn2050-084X
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (108070/Z/15/Z)
pubs.funder-project-idAddenbrooke's Charitable Trust (ACT) (900275 Minute 47/20B)
pubs.funder-project-idMedical Research Council (MR/P008801/1)
pubs.funder-project-idMRC (via University of Warwick) (MR/V038613/1)
cam.issuedOnline2021-11-16
cam.orpheus.counter1
rioxxterms.freetoread.startdate2024-11-10


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International