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dc.contributor.authorNakagomi, Daiki
dc.contributor.authorKronbichler, Andreas
dc.contributor.authorWitte, Torsten
dc.contributor.authorMohammad, Aladdin J
dc.contributor.authorJayne, David
dc.date.accessioned2021-11-13T00:30:11Z
dc.date.available2021-11-13T00:30:11Z
dc.date.issued2017-03
dc.identifier.issn1462-0324
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330619
dc.description.abstractSir, Takayasu arteritis (TAK) is a granulomatous vasculitis affecting large vessels, including the aorta and its main branches. It has a female preponderance and the diagnosis is usually made in the second or third decade of life. Imperfect activity scores mainly relying on a modified Birmingham Vasculitis Activity Score and scores including imaging have been proposed [1]. Treatment strategies used in the management of TAK are not evidence-based due to a paucity of randomised controlled trials. In general, disease-modifying anti-rheumatic drugs (DMARDs), including methotrexate (MTX), azathioprine (AZA), mycophenolate mofetil (MMF), leflunomide (LEF) and cyclophosphamide (CYC) in selected cases, alongside steroids are considered as mainstay of treatment. Furthermore, biologic agents such as TNF-α inhibitors, especially infliximab (IFX), interleukin-6 blockade with tocilizumab (TCZ) and B-cell depletion with rituximab (RTX) attracted attention due to efficacy in mainly refractory TAK cases [2].
dc.publisherBritish Society for Rheumatology
dc.rightsAll rights reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.titleComment on: Rituximab therapy for Takayasu arteritis: a seven patients experience and a review of the literature
dc.typeArticle
prism.endingPage1310
prism.issueIdentifier7
prism.publicationNameRheumatology
prism.startingPage1309
prism.volume57
dc.identifier.doi10.17863/CAM.78063
dcterms.dateAccepted2017-11-15
rioxxterms.versionofrecord10.1093/rheumatology/kex493
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-11-15
dc.contributor.orcidKronbichler, Andreas [0000-0002-2945-2946]
dc.contributor.orcidJayne, David [0000-0002-1712-0637]
dc.identifier.eissn1462-0332
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-01-29
cam.orpheus.success2021-11-12 - Embargo set during processing via Fast-track
rioxxterms.freetoread.startdate2019-01-29


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