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dc.contributor.authorHijazi, Zina
dc.contributor.authorYassi, Nawaf
dc.contributor.authorO'Brien, John
dc.contributor.authorWatson, Rosie
dc.date.accessioned2021-12-15T00:30:52Z
dc.date.available2021-12-15T00:30:52Z
dc.date.issued2022-04
dc.identifier.issn1351-5101
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331398
dc.description.abstractBACKGROUND AND PURPOSE: Lewy body dementia (LBD), including dementia with Lewy bodies (DLB) and Parkinson's disease dementia, is a common form of neurodegenerative dementia. The frequency and influence of comorbid cerebrovascular disease is not understood but has potentially important clinical management implications. METHODS: A systematic literature search was conducted (MEDLINE and Embase) for studies including participants with DLB and/or Parkinson's disease dementia assessing cerebrovascular lesions (imaging and pathological studies). They included white matter changes, cerebral amyloid angiopathy, cerebral microbleeds (CMB), macroscopic infarcts, microinfarcts and intracerebral haemorrhage. RESULTS: Of 4411 articles, 63 studies were included. Cerebrovascular lesions commonly studied included white matter changes (41 studies) and CMB (18 studies). There was an increased severity of white matter changes on magnetic resonance imaging (visualized as white matter hyperintensities), but not neuropathology, in LBD compared to Parkinson's disease without dementia and age-matched controls. CMB prevalence in DLB was highly variable but broadly similar to Alzheimer's disease (0%-48%), with a lobar predominance. No relationship was found between large cortical or small subcortical infarcts or intracerebral haemorrhage and the presence of LBD. CONCLUSION: The underlying mechanisms of white matter hyperintensities in LBD require further exploration, as their increased severity in LBD was not supported by neuropathological examination of white matter. CMB in LBD had a similar prevalence to Alzheimer's disease. There is a need for larger studies assessing the influence of cerebrovascular lesions on clinical symptoms, disease progression and outcomes.
dc.description.sponsorshipFunding: This work was supported by the Dementia Australia Research Fellowship award
dc.publisherWiley
dc.rightsAll Rights Reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.titleThe influence of cerebrovascular disease in dementia with Lewy bodies and Parkinson's disease dementia.
dc.typeArticle
dc.publisher.departmentDepartment of Psychiatry
dc.date.updated2021-12-10T17:40:47Z
prism.publicationNameEur J Neurol
dc.identifier.doi10.17863/CAM.78851
dcterms.dateAccepted2021-12-08
rioxxterms.versionofrecord10.1111/ene.15211
rioxxterms.versionAM
dc.contributor.orcidHijazi, Zina [0000-0002-8646-7351]
dc.contributor.orcidO'Brien, John [0000-0002-0837-5080]
dc.identifier.eissn1468-1331
rioxxterms.typeJournal Article/Review
cam.issuedOnline2022-01-20
cam.orpheus.successTue Feb 01 19:02:28 GMT 2022 - Embargo updated
cam.depositDate2021-12-10
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2022-12-19


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