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dc.contributor.authorCaglic, Iztok
dc.contributor.authorSushentsev, Nikita
dc.contributor.authorShah, Nimish
dc.contributor.authorWarren, Anne
dc.contributor.authorLamb, Benjamin W
dc.contributor.authorBarrett, Tristan
dc.date.accessioned2022-01-07T00:30:43Z
dc.date.available2022-01-07T00:30:43Z
dc.date.issued2022-08
dc.identifier.issn0846-5371
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332248
dc.description.abstractPURPOSE: To assess the added value of histological information for local staging of prostate cancer (PCa) by comparing the accuracy of multiparametric MRI alone (mpMRI) and mpMRI with biopsy Gleason grade (mpMRI+Bx). METHODS: 133 consecutive patients who underwent preoperative 3T-MRI and subsequent radical prostatectomy for PCa were included in this single-centre retrospective study. mpMRI imaging was reviewed independently by two uroradiologists for the presence of extracapsular extension (ECE) and seminal vesicle invasion (SVI) on a 5-point Likert scale. For second reads, the radiologists received results of targeted fused MR/US biopsy (mpMRI+Bx) prior to re-staging. RESULTS: The median patient age was 63 years (interquartile range (IQR) 58-67 years) and median PSA was 6.5 ng/mL (IQR 5.0-10.0 ng/mL). Extracapsular extension was present in 85/133 (63.9%) patients and SVI was present in 22/133 (16.5%) patients. For ECE prediction, mpMRI showed sensitivity and specificity of 63.5% and 81.3%, respectively, compared to 77.7% and 81.3% achieved by mpMRI+Bx. At an optimal cut-off value of Likert score ≥ 3, areas under the curves (AUCs) was .85 for mpMRI+Bx and .78 for mpMRI, P < .01. For SVI prediction, AUC was .95 for mpMRI+Bx compared to .92 for mpMRI; P = .20. Inter-reader agreement for ECE and SVI prediction was substantial for mpMRI (k range, .78-.79) and mpMRI+Bx (k range, .74-.79). CONCLUSIONS: MpMRI+Bx showed superior diagnostic performance with an increased sensitivity for ECE prediction but no significant difference for SVI prediction. Inter-reader agreement was substantial for both protocols. Integration of biopsy information adds value when staging prostate mpMRI.
dc.description.sponsorshipCancer Research UK (Cambridge Imaging Centre grant number C197/A16465)
dc.publisherSAGE Publications
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleIntegration of Prostate Biopsy Results with Pre-Biopsy Multiparametric Magnetic Resonance Imaging Findings Improves Local Staging of Prostate Cancer.
dc.typeArticle
dc.publisher.departmentDepartment of Radiology
dc.date.updated2022-01-05T14:31:08Z
prism.publicationNameCan Assoc Radiol J
dc.identifier.doi10.17863/CAM.79693
dcterms.dateAccepted2021-12-22
rioxxterms.versionofrecord10.1177/08465371211073158
rioxxterms.versionAM
dc.contributor.orcidCaglic, Iztok [0000-0002-3432-3540]
dc.contributor.orcidWarren, Anne [0000-0002-1170-7867]
dc.contributor.orcidBarrett, Tristan [0000-0002-1180-1474]
dc.identifier.eissn1488-2361
rioxxterms.typeJournal Article/Review
cam.issuedOnline2022-02-24
cam.orpheus.successWed Mar 23 10:26:21 GMT 2022 - Embargo updated
cam.orpheus.counter2
cam.depositDate2022-01-05
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2022-02-24


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International