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dc.contributor.authorKhoronenkova, SV
dc.date.accessioned2022-02-11T00:30:23Z
dc.date.available2022-02-11T00:30:23Z
dc.date.issued2016-12
dc.identifier.issn0006-2979
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/333864
dc.description.abstractATM is a master regulator of the cellular response to DNA damage. The classical mechanism of ATM activation involves its monomerization in response to DNA double-strand breaks, resulting in ATM-dependent phosphorylation of more than a thousand substrates required for cell cycle progression, DNA repair, and apoptosis. Here, new experimental evidence for non-canonical mechanisms of ATM activation in response to stimuli distinct from DNA double-strand breaks is discussed. It includes cytoskeletal changes, chromatin modifications, RNA-DNA hybrids, and DNA single-strand breaks. Noncanonical ATM activation may be important for the pathology of the multisystemic disease Ataxia Telangiectasia.
dc.format.mediumPrint
dc.publisherPleiades Publishing Ltd
dc.rightsAll Rights Reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.subjectAnimals
dc.subjectAtaxia Telangiectasia
dc.subjectAtaxia Telangiectasia Mutated Proteins
dc.subjectDNA
dc.subjectDNA Repair
dc.subjectDNA, Single-Stranded
dc.subjectEnzyme Activation
dc.subjectHumans
dc.subjectRNA
dc.titleMechanisms of Non-canonical Activation of Ataxia Telangiectasia Mutated.
dc.typeArticle
dc.publisher.departmentDepartment of Biochemistry
dc.date.updated2022-02-03T11:34:11Z
prism.endingPage1675
prism.issueIdentifier13
prism.publicationDate2016
prism.publicationNameBiochemistry (Mosc)
prism.startingPage1669
prism.volume81
dc.identifier.doi10.17863/CAM.81280
dcterms.dateAccepted2016-07-26
rioxxterms.versionofrecord10.1134/S0006297916130058
rioxxterms.versionAM
dc.contributor.orcidKhoronenkova, Svetlana [0000-0002-7439-9320]
dc.identifier.eissn1608-3040
rioxxterms.typeJournal Article/Review
cam.issuedOnline2017-01-06
cam.orpheus.success2022-02-10 - Embargo set during processing via Fast-track
cam.depositDate2022-02-03
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2018-01-06


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