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dc.contributor.authorSandovici, Ionel
dc.contributor.authorFernandez-Twinn, Denise S
dc.contributor.authorHufnagel, Antonia
dc.contributor.authorConstância, Miguel
dc.contributor.authorOzanne, Susan E
dc.date.accessioned2022-04-05T23:30:46Z
dc.date.available2022-04-05T23:30:46Z
dc.date.issued2022-05
dc.identifier.issn2522-5812
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/335812
dc.description.abstractStrong evidence suggests that early-life exposures to suboptimal environmental factors, including those in utero, influence our long-term metabolic health. This has been termed developmental programming. Mounting evidence suggests that the growth and metabolism of male and female fetuses differ. Therefore, sexual dimorphism in response to pre-conception or early-life exposures could contribute to known sex differences in susceptibility to poor metabolic health in adulthood. However, until recently, many studies, especially those in animal models, focused on a single sex, or, often in the case of studies performed during intrauterine development, did not report the sex of the animal at all. In this review, we (a) summarize the evidence that male and females respond differently to a suboptimal pre-conceptional or in utero environment, (b) explore the potential biological mechanisms that underlie these differences and (c) review the consequences of these differences for long-term metabolic health, including that of subsequent generations.
dc.publisherSpringer Science and Business Media LLC
dc.rightsAll Rights Reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.titleSex differences in the intergenerational inheritance of metabolic traits.
dc.typeArticle
dc.publisher.departmentDepartment of Clinical Biochemistry
dc.date.updated2022-04-05T14:06:58Z
prism.publicationNameNat Metab
dc.identifier.doi10.17863/CAM.83248
dcterms.dateAccepted2022-04-05
rioxxterms.versionofrecord10.1038/s42255-022-00570-4
rioxxterms.versionAM
dc.contributor.orcidSandovici, Ionel [0000-0001-5674-4269]
dc.contributor.orcidFernandez-Twinn, Denise S [0000-0003-2610-277X]
dc.contributor.orcidConstância, Miguel [0000-0002-8976-1679]
dc.contributor.orcidOzanne, Susan E [0000-0001-8753-5144]
dc.identifier.eissn2522-5812
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MC_UU_12012/4)
pubs.funder-project-idBritish Heart Foundation (RG/17/12/33167)
pubs.funder-project-idWellcome Trust (108926/B/15/Z)
pubs.funder-project-idMRC (MC_UU_00014/4)
cam.issuedOnline2022-05-30
cam.orpheus.successWed Jun 08 08:57:08 BST 2022 - Embargo updated
cam.orpheus.counter3
cam.depositDate2022-04-05
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2022-11-30


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