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dc.contributor.authorGurke, Johannes
dc.contributor.authorNaegele, Tobias E
dc.contributor.authorHilton, Sam
dc.contributor.authorPezone, Roberto
dc.contributor.authorCurto, Vincenzo F
dc.contributor.authorBarone, Damiano G
dc.contributor.authorList-Kratochvil, Emil JW
dc.contributor.authorCarnicer-Lombarte, Alejandro
dc.contributor.authorMalliaras, George G
dc.date.accessioned2022-04-21T23:30:43Z
dc.date.available2022-04-21T23:30:43Z
dc.date.issued2022-06-06
dc.identifier.issn2051-6347
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/336349
dc.description.abstractNew fabrication approaches for mechanically flexible implants hold the key to advancing the applications of neuroengineering in fundamental neuroscience and clinic. By combining the high precision of thin film microfabrication with the versatility of additive manufacturing, we demonstrate a straight-forward approach for the prototyping of intracranial implants with electrode arrays and microfluidic channels. We show that the implant can modulate neuronal activity in the hippocampus through localized drug delivery, while simultaneously recording brain activity by its electrodes. Moreover, good implant stability and minimal tissue response are seen one-week post-implantation. Our work shows the potential of hybrid fabrication combining different manufacturing techniques in neurotechnology and paves the way for a new approach to the development of multimodal implants.
dc.publisherRoyal Society of Chemistry (RSC)
dc.rightsAll Rights Reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.titleHybrid fabrication of multimodal intracranial implants for electrophysiology and local drug delivery.
dc.typeArticle
dc.publisher.departmentDepartment of Engineering
dc.date.updated2022-04-21T10:25:50Z
prism.publicationNameMater Horiz
dc.identifier.doi10.17863/CAM.83769
dcterms.dateAccepted2022-04-21
rioxxterms.versionofrecord10.1039/d1mh01855h
rioxxterms.versionAM
dc.contributor.orcidGurke, Johannes [0000-0002-3081-8087]
dc.contributor.orcidNaegele, Tobias E [0000-0002-1842-6750]
dc.contributor.orcidList-Kratochvil, Emil JW [0000-0001-9206-800X]
dc.contributor.orcidCarnicer-Lombarte, Alejandro [0000-0002-5650-4692]
dc.contributor.orcidMalliaras, George G [0000-0002-4582-8501]
dc.identifier.eissn2051-6355
rioxxterms.typeJournal Article/Review
pubs.funder-project-idEngineering and Physical Sciences Research Council (EP/S009000/1)
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Future and Emerging Technologies (FET) (732032)
pubs.funder-project-idEngineering and Physical Sciences Research Council (EP/L015978/1)
cam.issuedOnline2022-06-06
cam.orpheus.successWed May 25 11:13:41 BST 2022 - Embargo updated
cam.orpheus.counter1
cam.depositDate2022-04-21
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2023-04-27


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