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dc.contributor.authorTopiwala, A
dc.contributor.authorTaschler, B
dc.contributor.authorEbmeier, KP
dc.contributor.authorSmith, S
dc.contributor.authorZhou, H
dc.contributor.authorLevey, DF
dc.contributor.authorCodd, V
dc.contributor.authorSamani, NJ
dc.contributor.authorGelernter, J
dc.contributor.authorNichols, TE
dc.contributor.authorBurgess, S
dc.date.accessioned2022-06-27T23:31:22Z
dc.date.available2022-06-27T23:31:22Z
dc.date.issued2022-07-26
dc.identifier.issn1359-4184
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338392
dc.description.abstractAlcohol's impact on telomere length, a proposed marker of biological aging, is unclear. We performed the largest observational study to date (in n = 245,354 UK Biobank participants) and compared findings with Mendelian randomization (MR) estimates. Two-sample MR used data from 472,174 participants in a recent genome-wide association study (GWAS) of telomere length. Genetic variants were selected on the basis of associations with alcohol consumption (n = 941,280) and alcohol use disorder (AUD) (n = 57,564 cases). Non-linear MR employed UK Biobank individual data. MR analyses suggested a causal relationship between alcohol traits, more strongly for AUD, and telomere length. Higher genetically-predicted AUD (inverse variance-weighted (IVW) β = -0.06, 95% confidence interval (CI): -0.10 to -0.02, p = 0.001) was associated with shorter telomere length. There was a weaker association with genetically-predicted alcoholic drinks weekly (IVW β = -0.07, CI: -0.14 to -0.01, p = 0.03). Results were consistent across methods and independent from smoking. Non-linear analyses indicated a potential threshold relationship between alcohol and telomere length. Our findings indicate that alcohol consumption may shorten telomere length. There are implications for age-related diseases.
dc.publisherSpringer Science and Business Media LLC
dc.rightsAll Rights Reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.titleAlcohol consumption and telomere length: Mendelian randomization clarifies alcohol's effects.
dc.typeArticle
dc.publisher.departmentMrc Biostatistics Unit
dc.date.updated2022-06-27T09:58:30Z
prism.publicationNameMol Psychiatry
dc.identifier.doi10.17863/CAM.85804
dcterms.dateAccepted2022-06-29
rioxxterms.versionofrecord10.1038/s41380-022-01690-9
rioxxterms.versionAM
dc.contributor.orcidTopiwala, A [0000-0002-8408-0372]
dc.contributor.orcidTaschler, B [0000-0001-6574-4789]
dc.contributor.orcidEbmeier, KP [0000-0002-5190-7038]
dc.contributor.orcidZhou, H [0000-0002-7694-6391]
dc.contributor.orcidLevey, DF [0000-0001-8431-9569]
dc.contributor.orcidGelernter, J [0000-0002-4067-1859]
dc.contributor.orcidNichols, TE [0000-0002-4516-5103]
dc.contributor.orcidBurgess, S [0000-0001-5365-8760]
dc.identifier.eissn1476-5578
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (204623/Z/16/Z)
pubs.funder-project-idMedical Research Council (MR/M012816/1)
pubs.funder-project-idNational Institute for Health Research (IS-BRC-1215-20014)
cam.issuedOnline2022-07-26
cam.orpheus.successWed Aug 03 09:45:57 BST 2022 - Embargo updated
cam.orpheus.counter2
cam.depositDate2022-06-27
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2023-01-26


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