Show simple item record

dc.contributor.authorJung, Audrey Y
dc.contributor.authorAhearn, Thomas U
dc.contributor.authorBehrens, Sabine
dc.contributor.authorMiddha, Pooja
dc.contributor.authorBolla, Manjeet K
dc.contributor.authorWang, Qin
dc.contributor.authorArndt, Volker
dc.contributor.authorAronson, Kristan J
dc.contributor.authorAugustinsson, Annelie
dc.contributor.authorBeane Freeman, Laura E
dc.contributor.authorBecher, Heiko
dc.contributor.authorBrenner, Hermann
dc.contributor.authorCanzian, Federico
dc.contributor.authorCarey, Lisa A
dc.contributor.authorCTS Consortium
dc.contributor.authorCzene, Kamila
dc.contributor.authorEliassen, A Heather
dc.contributor.authorEriksson, Mikael
dc.contributor.authorEvans, D Gareth
dc.contributor.authorFigueroa, Jonine D
dc.contributor.authorFritschi, Lin
dc.contributor.authorGabrielson, Marike
dc.contributor.authorGiles, Graham G
dc.contributor.authorGuénel, Pascal
dc.contributor.authorHadjisavvas, Andreas
dc.contributor.authorHaiman, Christopher A
dc.contributor.authorHåkansson, Niclas
dc.contributor.authorHall, Per
dc.contributor.authorHamann, Ute
dc.contributor.authorHoppe, Reiner
dc.contributor.authorHopper, John L
dc.contributor.authorHowell, Anthony
dc.contributor.authorHunter, David J
dc.contributor.authorHüsing, Anika
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorKosma, Veli-Matti
dc.contributor.authorKoutros, Stella
dc.contributor.authorKraft, Peter
dc.contributor.authorLacey, James V
dc.contributor.authorLe Marchand, Loic
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorLoizidou, Maria A
dc.contributor.authorMannermaa, Arto
dc.contributor.authorMaurer, Tabea
dc.contributor.authorMurphy, Rachel A
dc.contributor.authorOlshan, Andrew F
dc.contributor.authorOlsson, Håkan
dc.contributor.authorPatel, Alpa V
dc.contributor.authorPerou, Charles M
dc.contributor.authorRennert, Gad
dc.contributor.authorShibli, Rana
dc.contributor.authorShu, Xiao-Ou
dc.contributor.authorSouthey, Melissa C
dc.contributor.authorStone, Jennifer
dc.contributor.authorTamimi, Rulla M
dc.contributor.authorTeras, Lauren R
dc.contributor.authorTroester, Melissa A
dc.contributor.authorTruong, Thérèse
dc.contributor.authorVachon, Celine M
dc.contributor.authorWang, Sophia S
dc.contributor.authorWolk, Alicja
dc.contributor.authorWu, Anna H
dc.contributor.authorYang, Xiaohong R
dc.contributor.authorZheng, Wei
dc.contributor.authorDunning, Alison M
dc.contributor.authorPharoah, Paul DP
dc.contributor.authorEaston, Douglas F
dc.contributor.authorMilne, Roger L
dc.contributor.authorChatterjee, Nilanjan
dc.contributor.authorSchmidt, Marjanka K
dc.contributor.authorGarcía-Closas, Montserrat
dc.contributor.authorChang-Claude, Jenny
dc.date.accessioned2022-07-01T23:30:48Z
dc.date.available2022-07-01T23:30:48Z
dc.date.issued2022-12-08
dc.identifier.issn0027-8874
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338682
dc.description.abstractBACKGROUND: Reproductive factors have been shown to be differentially associated with risk of estrogen receptor (ER)-positive and ER-negative breast cancer. However, their associations with intrinsic-like subtypes are less clear. METHODS: Analyses included up to 23 353 cases and 71 072 controls pooled from 31 population-based case-control or cohort studies in the Breast Cancer Association Consortium across 16 countries on 4 continents. Polytomous logistic regression was used to estimate the association between reproductive factors and risk of breast cancer by intrinsic-like subtypes (luminal A-like, luminal B-like, luminal B-HER2-like, HER2-enriched-like, and triple-negative breast cancer) and by invasiveness. All statistical tests were 2-sided. RESULTS: Compared with nulliparous women, parous women had a lower risk of luminal A-like, luminal B-like, luminal B-HER2-like, and HER2-enriched-like disease. This association was apparent only after approximately 10 years since last birth and became stronger with increasing time (odds ratio [OR] = 0.59, 95% confidence interval [CI] = 0.49 to 0.71; and OR = 0.36, 95% CI = 0.28 to 0.46 for multiparous women with luminal A-like tumors 20 to less than 25 years after last birth and 45 to less than 50 years after last birth, respectively). In contrast, parous women had a higher risk of triple-negative breast cancer right after their last birth (for multiparous women: OR = 3.12, 95% CI = 2.02 to 4.83) that was attenuated with time but persisted for decades (OR = 1.03, 95% CI = 0.79 to 1.34, for multiparous women 25 to less than 30 years after last birth). Older age at first birth (Pheterogeneity < .001 for triple-negative compared with luminal A-like breast cancer) and breastfeeding (Pheterogeneity < .001 for triple-negative compared with luminal A-like breast cancer) were associated with lower risk of triple-negative breast cancer but not with other disease subtypes. Younger age at menarche was associated with higher risk of all subtypes; older age at menopause was associated with higher risk of luminal A-like but not triple-negative breast cancer. Associations for in situ tumors were similar to luminal A-like. CONCLUSIONS: This large and comprehensive study demonstrates a distinct reproductive risk factor profile for triple-negative breast cancer compared with other subtypes, with implications for the understanding of disease etiology and risk prediction.
dc.format.mediumPrint-Electronic
dc.publisherOxford University Press (OUP)
dc.rightsAll Rights Reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.subjectbreast cancer
dc.subjectintrinsic-like subtypes
dc.subjectreproductive risk factors
dc.subjecttriple-negative
dc.titleDistinct Reproductive Risk Profiles for Intrinsic-Like Breast Cancer Subtypes: Pooled Analysis of Population-Based Studies.
dc.typeArticle
dc.publisher.departmentDepartment of Public Health And Primary Care, Cancer Genetic Epidemiology
dc.date.updated2022-06-30T14:05:23Z
prism.publicationDate2022
prism.publicationNameJ Natl Cancer Inst
prism.startingPagedjac117
dc.identifier.doi10.17863/CAM.86095
dcterms.dateAccepted2022-05-03
rioxxterms.versionofrecord10.1093/jnci/djac117
rioxxterms.versionAM
dc.contributor.orcidJung, Audrey Y [0000-0003-0875-6673]
dc.contributor.orcidAhearn, Thomas U [0000-0003-0771-7752]
dc.contributor.orcidBehrens, Sabine [0000-0002-9714-104X]
dc.contributor.orcidMiddha, Pooja [0000-0001-5503-8215]
dc.contributor.orcidWang, Qin [0000-0002-9139-0627]
dc.contributor.orcidArndt, Volker [0000-0001-9320-8684]
dc.contributor.orcidAronson, Kristan J [0000-0002-7865-7243]
dc.contributor.orcidBecher, Heiko [0000-0002-8808-6667]
dc.contributor.orcidBrenner, Hermann [0000-0002-6129-1572]
dc.contributor.orcidCanzian, Federico [0000-0002-4261-4583]
dc.contributor.orcidCzene, Kamila [0000-0002-3233-5695]
dc.contributor.orcidEliassen, A Heather [0000-0002-3961-6609]
dc.contributor.orcidFigueroa, Jonine D [0000-0002-5100-623X]
dc.contributor.orcidFritschi, Lin [0000-0002-7692-3560]
dc.contributor.orcidGabrielson, Marike [0000-0002-3171-1556]
dc.contributor.orcidGiles, Graham G [0000-0003-4946-9099]
dc.contributor.orcidGuénel, Pascal [0000-0002-8359-518X]
dc.contributor.orcidHadjisavvas, Andreas [0000-0002-5636-0799]
dc.contributor.orcidHåkansson, Niclas [0000-0001-7673-5554]
dc.contributor.orcidHall, Per [0000-0002-5640-9126]
dc.contributor.orcidHüsing, Anika [0000-0002-2685-9732]
dc.contributor.orcidKoutros, Stella [0000-0001-5294-5485]
dc.contributor.orcidKraft, Peter [0000-0002-4472-8103]
dc.contributor.orcidLe Marchand, Loic [0000-0001-5013-980X]
dc.contributor.orcidLissowska, Jolanta [0000-0003-2695-5799]
dc.contributor.orcidLoizidou, Maria A [0000-0003-4503-7758]
dc.contributor.orcidMannermaa, Arto [0000-0001-8250-1930]
dc.contributor.orcidMurphy, Rachel A [0000-0003-4383-5641]
dc.contributor.orcidOlsson, Håkan [0000-0002-7721-4619]
dc.contributor.orcidPatel, Alpa V [0000-0001-8834-9896]
dc.contributor.orcidPerou, Charles M [0000-0001-9827-2247]
dc.contributor.orcidShu, Xiao-Ou [0000-0002-0711-8314]
dc.contributor.orcidSouthey, Melissa C [0000-0002-6313-9005]
dc.contributor.orcidStone, Jennifer [0000-0001-5077-0124]
dc.contributor.orcidTamimi, Rulla M [0000-0003-2306-8668]
dc.contributor.orcidVachon, Celine M [0000-0002-1962-9322]
dc.contributor.orcidWolk, Alicja [0000-0001-7387-6845]
dc.contributor.orcidDunning, Alison M [0000-0001-6651-7166]
dc.contributor.orcidPharoah, Paul DP [0000-0001-8494-732X]
dc.contributor.orcidEaston, Douglas F [0000-0003-2444-3247]
dc.contributor.orcidMilne, Roger L [0000-0001-5764-7268]
dc.contributor.orcidSchmidt, Marjanka K [0000-0002-2228-429X]
dc.contributor.orcidGarcía-Closas, Montserrat [0000-0003-1033-2650]
dc.contributor.orcidChang-Claude, Jenny [0000-0001-8919-1971]
dc.identifier.eissn1460-2105
rioxxterms.typeJournal Article/Review
pubs.funder-project-idCancer Research Uk (None)
pubs.funder-project-idCancer Research UK (20861)
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Societal Challenges (634935)
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Societal Challenges (633784)
pubs.funder-project-idMedical Research Council (G1000143)
pubs.funder-project-idNational Cancer Institute (U19CA148065)
pubs.funder-project-idNational Cancer Institute (P30CA023100)
cam.issuedOnline2022-06-20
cam.orpheus.success2022-07-01 - Embargo set during processing via Fast-track
cam.depositDate2022-06-30
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2023-06-20


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record